Network Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Sun, Taoli;Quan, Wenjuan;Peng, Sha;Yang, Dongmei;Liu, Jiaqin;...

通讯作者：

Qinhui Tuo

作者机构：

[Sun, Taoli; He, Chaoping; Quan, Wenjuan; Peng, Sha] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

[Chen, Yu; Hu, Bo; Tuo, Qinhui; Yang, Dongmei] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Peoples R China.

[Liu, Jiaqin] Cent South Univ, Xiangya Hosp 1, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

[Tuo, Qinhui] Hunan Univ Chinese Med, First Hosp, Changsha 410007, Peoples R China.

通讯机构：

[Qinhui Tuo] S

School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China<&wdkj&>The First hospital of Hunan University of Chinese Medicine, Changsha, 410007, People’s Republic of China

语种：

英文

关键词：

Huo Luo Xiao Ling Dan;atherosclerosis;network pharmacology;molecular docking;molecular dynamics simulation;dihydrotanshinone I;STAT3;MAPK signaling pathway

期刊：

Drug Design, Development and Therapy

ISSN：

1177-8881

年：

2022

卷：

页码：

1621-1645

DOI：

10.2147/DDDT.S357483

基金类别：

National Natural Science Foundation of China [81600291]; key research and development projects of Hunan Provincial Science and Technology Department [2022SK2011]; science and technol-ogy innovation Program of Hunan Province [2021RC4064]

机构署名：

本校为第一机构

院系归属：

医学院

药学院

摘要：

Background: Huo Luo Xiao Ling Dan (HLXLD), a famous Traditional Chinese Medicine (TCM) classical formula, possesses anti-atherosclerosis (AS) activity. However, the underlying molecular mechanisms remain obscure. Aim: The network pharmacology approach, molecular docking strategy, and in vitro validation experiment were performed to explore the potential active compounds, key targets, main signaling pathways, and underlying molecular mechanisms of HLXLD in treating AS. Methods: Several public databases were used to search for active components a...

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Network Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis

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