PD-1/PD-L1 inhibitors associated hypophysitis: An analysis from the FAERS database and case reports.

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成果类型：

期刊论文

作者：

Chen, Shanshan;Ouyang, Linqi;Li, Lian;Xiao, Yuyang;Wang, Shengfeng

作者机构：

[Chen, Shanshan; Wang, Shengfeng] Department of Pharmacy, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China

[Ouyang, Linqi] Department of Pharmacy, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China

[Li, Lian] Department of Information, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China

[Xiao, Yuyang] Xiangya School of Medicine, Central South University, Changsha, Hunan, China

[Wang, Shengfeng] Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

语种：

英文

关键词：

PD-1/PD-L1 inhibitors;characteristic;disproportionality analysis;hypophysitis;managements

期刊：

Drug Discoveries & Therapeutics

ISSN：

1881-7831

年：

2024

卷：

期：

页码：

34-43

DOI：

10.5582/ddt.2023.01092

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

To get a thorough understanding of PD-1/L1 inhibitor-related hypophysitis (PD-1/L1-irH), we utilized a combination of disproportionality analysis and case analysis to comprehensively characterize the clinical features of PD-1/L1-irH. Significant signals of hypophysitis were detected for all PD-1/PD-L1 inhibitors in the FAERS (FDA Adverse Event Reporting System). As revealed by both FAERS and the case analysis, PD-1/L1-irH occurred more commonly in males, PD-1 inhibitors users and patients older than 65 years. The median onset time was 101 days in FAERS and 8 cycles in the case analysis. In the...

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PD-1/PD-L1 inhibitors associated hypophysitis: An analysis from the FAERS database and case reports.

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