This work was supported by grants from The Key Projects of Hunan province Science and Technology Plan ( 2017SK2032 ), Medical Scientific Research Foundation of Guangdong Province of China ( A2019155 ), China Postdoctoral Science Foundation ( 2019M650358 ), Ministry of Education Humanities and Social Science Fund ( 18YJC190004 ), the Hunan Province Natural Fund ( 2017JJ3240 ).