期刊论文

Investigation on the Effects and Mechanism of Jiuqi Niantong Capsule (JQNTC) on Oxytocin-Induced Dysmenorrhea Rats

中文

湖南中医药大学学报

1674-070X

2005

25

2

7-10

10.3969/j.issn.1674-070X.2005.02.003

湖南省卫生厅中医药科研基金资助项目 （2 0 0 0 77）,国药准字 （Z2 0 0 10 0 0 9）,国药证字 （Z2 0 0 10 0 0 6）；

本校为第一机构

目的探讨九气拈痛胶囊对原发性痛经的镇痛作用机制.方法采用催产素所致大鼠子宫剧烈收缩造成痛经模型,拟九气拈痛胶囊3个不同剂量组,设阿司匹林、月月舒冲剂(分别为阳性组)为对照组,分别观察用药后大鼠30min内的扭体次数和扭体发生率,血液流变学指标,血浆中β-EP、TXB2、6-K-PGF1α、子宫组织中PGF2α、PGE2、NO、ET-1各项指标的变化.结果 (1)九气拈痛胶囊3个剂量组30min内的扭体发生次数及其发生率分别与模型组比较具有显著性意义(P＜0.05,P＜0.01);(2)胶囊各剂量组均可改善血液流变性如全血黏度、血浆比黏度、红细胞压积、红细胞电泳时间,与模型组比较具有显著性意义(P＜0.05,P＜0.01);(3)胶囊...

Objective To explore the effects and the mechanism of JQNTC on primary dysmenorrhea. Methods Oxytocin induced dysmenorrhea rats were divided into modeling group, positive controlling groups (i.e. Aspirin treated group and Yueyueshu group) and three treating groups, with JQNTC given in low, medium and high dosages respectively. The number and occurrence rate of writhing (WR), the property indices of hemorheology, i.e β EP,TXB 2,6 Keto PGF 1α in plasma, and the changes of PGF 2α ,PGE 2, NO, ET 1 in uterus tissue were observed. Results Compared...