Organoantimony (III) Derivative Induces Necroptosis in Human Breast Cancer MDA-MB-231 Cells

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成果类型：

期刊论文

作者：

Liu, Yong-Ping;Lei, Jian;Yin, Ming-Ming;Chen, Yi

通讯作者：

Liu, Y.-P.

作者机构：

[Chen, Yi; Liu, Yong-Ping] Hunan Univ Chinese Med, Sch Med, Dept Physiol, 300 Xueshi Rd,Hanpu Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.

[Lei, Jian] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Yin, Ming-Ming] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

Department of Physiology, School of Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Hanpu Science and Education Park, Yuelu District Hunan, Changsha, China

语种：

英文

关键词：

Metal complex;necroptosis inducer;anti-cancer;triple-negative breast cancer;ROS;oxidative stress.

期刊：

Anti-Cancer Agents in Medicinal Chemistry

ISSN：

1871-5206

年：

2022

卷：

期：

页码：

2448-2457

DOI：

10.2174/1871520622666220118093643

基金类别：

National Natural Science Foundation of China [21571060]; Natural Science Foundation of Hunan Province [2019JJ40222]; Hunan University of Traditional Chinese Medicine First-class Discipline Open Fund of Integrated Traditional Chinese and Western Medicine [2020ZXYJH68]

机构署名：

本校为第一机构

院系归属：

医学院

中西医结合学院

摘要：

Aim: This study aimed to investigate the anticancer effect and the underlying mechanisms of organoantimony (III) fluoride on MDA-MB-231 human breast cancer cells. Methods: Five cancer and one normal cell line were treated with an organoantimony (III) compound 6-cyclohexyl-12- fluoro-5,6,7,12-tetrahydrodibenzo[c,f][1,5]azastibocine (denoted as C4). The cell viability was detected by MTT assay. Induction of cell death was determined by Hoechst 33342/PI staining and Annexin-V/PI staining. The effect of C4 on the necroptotic relative protein was determined by Western blot analysis. Results: Among ...

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Organoantimony (III) Derivative Induces Necroptosis in Human Breast Cancer MDA-MB-231 Cells

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