Antibacterial Effects of a Cell-Penetrating Peptide Isolated from Kefir

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Miao, Jianyin;Guo, Haoxian;Chen, Feilong;Zhao, Lichao;He, Liping;...

通讯作者：

Cao, Yong;Huang, Qingrong

作者机构：

[Huang, Manman; Cao, Yong; Miao, Jianyin; Guo, Haoxian; Zhang, Yi; Chen, Feilong; Guo, Baoyan; Zhao, Lichao; He, Liping] South China Agr Univ, Coll Food Sci, Guangzhou 510642, Guangdong, Peoples R China.

[Cao, Yong; Miao, Jianyin; Chen, Feilong; Zhao, Lichao; He, Liping] Guangdong Prov Engn Res Ctr Bioact Nat Prod, Guangzhou 510642, Guangdong, Peoples R China.

[Miao, Jianyin] Qinzhou Univ, Qinzhou 535000, Peoples R China.

[Huang, Qingrong] Rutgers State Univ, Dept Food Sci, 65 Dudley Rd, New Brunswick, NJ 08901 USA.

[Ou, Yangwen] Hunan Univ Chinese Med, Sch Pharm, Changsha 410000, Hunan, Peoples R China.

通讯机构：

[Cao, Yong] S

[Cao, Yong] G

[Huang, Qingrong] R

South China Agr Univ, Coll Food Sci, Guangzhou 510642, Guangdong, Peoples R China.

Guangdong Prov Engn Res Ctr Bioact Nat Prod, Guangzhou 510642, Guangdong, Peoples R China.

语种：

英文

关键词：

kefir;antimicrobial peptide;purification;identification;antibacterial effects

期刊：

Journal of Agricultural and Food Chemistry

ISSN：

0021-8561

年：

2016

卷：

期：

页码：

3234-3242

DOI：

10.1021/acs.jafc.6b00730

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31171768]; Scientific Research Project of Guangdong Province Office of Education [2013gjhz0003]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Kefir is a traditional fermented milk beverage used throughout the world for centuries. A cell-penetrating peptide, F3, was isolated from kefir by Sephadex G-50 gel filtration, DEAE-52 ion exchange, and reverse-phase high-performance liquid chromatography. F3 was determined to be a low molecular weight peptide containing one leucine and one tyrosine with two phosphate radicals. This peptide displayed antimicrobial activity across a broad spectrum of organisms including several Gram-positive and Gram-negative bacteria as well as fungi, with minimal inhibitory concentration (MIC) values ranging ...

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