期刊论文

Effect of Jiaweidanshenyin Preconditioning on the Electrocardiograph of Rabbits with Ischemical Reperfusion Injury

中文

中医药导报

1672-951X

2003

9

11

56-58

10.13862/j.cnki.cn43-1446/r.2003.11.032

湖南省自然科学基金

本校为第一机构

目的:探讨加味丹参饮预处理对缺血再灌注损伤家兔心电图的影响.方法:将健康家兔32只,随机分为假手术组(Shm)、缺血再灌注组(I/R)、药物预处理组(DP)和缺血预处理组(IP),每组8只,分别预处理24h后行心肌缺血60min、再灌注120min,观察家兔心率、Ⅱ导联心电图ST段等的变化.结果:I/R家兔标准Ⅱ导联心电图心率明显减慢、ST段明显抬高或T波倒置,并且绝大部分家兔出现心律失常(87.5%);而药物预处理和缺血预处理对ST段抬高或T波倒置以及心律失常有明显的改善作用(P＜0.05),对心率变化作用不明显(P＞0.05).结论:加味丹参饮预处理对家兔缺血再灌注损伤心肌有明显的延迟保护作用.

Objective: To observe the effect of Jiaweidanshenyin preconditioning on the Electrocardiograph (ECG)of rabbits with ischemical reperfusion injury. Methods:Thirty-two chronically instrumented conscious rabbits successfully underwent the following protocol. Rabbits were randomly divided into four groups: Sham (saline, duodenum), I/R (saline, duodenum), DP (Jiaweidanshenyin, 5.86g/kg,duodenum), IP (four 5-min coronary artery occlusion / 10-min reperfusion cycles). On two day (24h later), rabbits(except the Sham's) underwent a 60-min coronary arter...