期刊论文

Effects of statins on ICAM-1、ET-1 and MMP-9 and their correlation with hemorrhage transformation after thrombolysis with alteplase

中文

脑与神经疾病杂志

1006-351X

2020

28

8

481-485

(C2016017):湖南省卫生计生委重点科研计划课题

本校为第一机构

目的 探讨他汀类药物对阿替普酶(rt-PA)溶栓后血清细胞间黏附分子(ICAM-1)、内皮素-1(ET-1)、血浆基质金属蛋白酶(MMP-9)水平的变化及其与溶栓后颅内出血转化的相关性分析.方法 选取湖南省脑科医院2016年08月-2019年09月诊治的rt-PA静脉溶栓患者共100例;将入组对象分为两组,对照组:非他汀药物+rt-PA溶栓+标准药物治疗;实验组:他汀药物+rt-PA溶栓+标准药物治疗.将两组患者均进行静脉溶栓治疗,分别在溶栓后1h、6h、12h、24h静脉采集患者肘部静脉血清,采用酶联免疫吸附法(ELISA)检测ICAM-1、ET-1、MMP-9水平.静脉溶栓治疗后病情变化考虑出血时及24h完善头颅CT明确颅内出血情况.结果 组间比较,长期服...

Objective To investigate the changes of serum intercellular adhesion molecules(ICAM-1),endothelin-1(ET-1)and plasma matrix metalloproteinase(MMP-9)after thrombolysis of alteplase(rt-PA)by statins and their correlation with the transformation of intracranial hemorrhage after thrombolysis.Methods We collected 100 patients with thrombolytic ischemic stroke of rt-PA admitted to hunan brain hospital from August 2016 to September 2019.These individuals were randomly divided into two groups.The control group was non-statin group,and received conventio...