期刊论文

Synthesis of N,N-alkyl-2-methylamine Alkyl Amides

中文

合成化学

1005-1511

2018

26

2

105-110

10.15952/j.cnki.cjsc.1005-1511.2018.02.17118

湖南省教育厅项目（17C1624） 岳阳市科技项目（科发【2014】41）

本校为其他机构

以羧酸和环状仲胺为原料,二氯甲烷为溶剂,1-羟基-苯并-三氮唑(HOBT)和1-(3-二甲氨基丙基)-3-乙基碳化二亚胺盐酸盐(EDCI)为缩合剂,合成了一系列含咪唑环和吡嗪环的N-烷基酰胺衍生物,收率56%~73%,其结构经~1H NMR, ~(13)C NMR和MS(ESI)确证。

A series of N-alkyl derivatives containing imidazole and pyrazine ring with yields of 56%~73% were synthesized from carboxylic acid and cyclic secondary amines, using HOBT and EDCI as condensing agent, DCM as solvent. The structures were confirmed by ~1...