RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ss and JNK signaling pathways in dopaminergic neuron-like cells.

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成果类型：

期刊论文

作者：

Zhang, Xiao-Ling;Wang, Zhen-Zhen;Shao, Qian-Hang;Zhang, Zhao;Li, Lin;...

通讯作者：

Chen, NH;Zhang, Y

作者机构：

[Wang, Zhen-Zhen; Shao, Qian-Hang; Zhang, Xiao-Ling; Chen, Nai-Hong; Zhang, Zhao] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.

[Wang, Zhen-Zhen; Shao, Qian-Hang; Zhang, Xiao-Ling; Chen, Nai-Hong; Zhang, Zhao] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Wang, Zhen-Zhen; Shao, Qian-Hang; Zhang, Xiao-Ling; Chen, Nai-Hong; Zhang, Zhao; Chen, NH] Peking Union Med Coll, 1 Xian Nong Tan St, Beijing 100050, Peoples R China.

[Chen, Nai-Hong] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

[Li, Lin] Capital Med Univ, Key Lab Neurodegenerat Dis, Minist Educ, Beijing 100053, Peoples R China.

通讯机构：

[Chen, NH ] P

[Zhang, Y ] B

Peking Union Med Coll, 1 Xian Nong Tan St, Beijing 100050, Peoples R China.

Beijing Univ Chinese Med, Dept Anat, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.

Chinese Acad Med Sci, Dept Pharmacol, Inst Mat Med, 1 Xian Nong Tan St, Beijing 100050, Peoples R China.

语种：

英文

关键词：

Akt;DJ-1;Mitochondrial dysfunction;Nuclear factor erythroid 2 (Nrf2);c-Jun N-terminal kinase (JNK)

期刊：

Brain Research Bulletin

ISSN：

0361-9230

年：

2019

卷：

146

页码：

228-236

DOI：

10.1016/j.brainresbull.2019.01.007

基金类别：

This work was financially supported by the National Natural Science Foundation of China ( 81473376 , U1402221 , 81573640 , 81773925 , 81573773 , 81603316 ), Beijing Natural Science Foundation ( 7161011 ), the Open Program of Key Laboratory for Neurodegenerative Diseases of Ministry of Education (Capital Medical University) ( 2016SJBX03 ), CAMS Innovation Fund for Medical Sciences (CIFMS, 2016-I2M-1-004 ), the Scientific Research Foundation of the Higher Education Institutions of Hunan Province ( 15K091 ), and the Follow-Up Research Project of Beijing University of Chinese Medicine (No. 81202939 ).

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本校为其他机构

院系归属：

药学院

摘要：

Deletions or some mutations in the gene encoding the multifunctional protein, DJ-1, have been considered to be linked with autosomal recessive early onset Parkinson's disease (PD). Current emerging evidence suggests that DJ-1 is involved in the protection against oxidative stress-induced mitochondrial damage. However, the exact molecular mechanisms underlying this are not completely clear. The aim of this study was to investigate the effects of DJ-1 on the Akt pathway, nuclear factor erythroid 2-related factor (Nrf2), and c-Jun N-terminal kinas...

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RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ss and JNK signaling pathways in dopaminergic neuron-like cells.

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