Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Chao;Li, Zhaoyong;Li, Linghui;Li, Shuofu;Yang, Lei;...

作者机构：

[Yang, Shaofeng; Zhang, Chao; Li, Zhaoyong; Guo, Yantao] Hunan Univ Chinese Med, Spine Orthoped Dept, Hosp 1, Changsha 410007, Peoples R China.

[Li, Linghui] Chinese Acad Tradit Chinese Med, Wangjing Hosp, Beijing, Peoples R China.

[Zhang, Xiao; Li, Shuofu; Chen, Long] Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.

[Yang, Lei] Hunan Univ Tradit Chinese Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Achyranthoside D;autophagy;intervertebral disc degeneration;nucleus pulposus;PI3K;Akt;mTOR

期刊：

Journal of Orthopaedic Surgery

ISSN：

1022-5536

年：

2022

卷：

期：

DOI：

10.1177/10225536221135474

基金类别：

Natural Science Foundation of Hunan Province [2020JJ5443]; National Natural Science Foundation [82174402]; Project of Health and Family Planning Commission of Hunan Province [202204074858]; School level key project of Hunan University of Chinese Medicine [2021XJJJ041]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Journal of Orthopaedic Surgery, Volume 30, Issue 3, September-December 2022. PurposeThis study aims to explore the potential mechanism of Achyranthoside D (AD) in improving intervertebral disc (IVD) degeneration (IDD).MethodsThe IDD model of SD rats and nucleus pulposus cells (NPCs) was established by lumbar cone annulus puncture and tert-butyl peroxide, respectively. Cell proliferation was detected by CCK8 assay. Apoptosis was detected by flow cytometry and TUNEL staining. IVD tissue injury was observed by HE staining. Alcian blue staining obs...

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Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway

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