MicroRNA-2355-5p Promotes the Proliferation of Head and Neck Squamous Cell Carcinoma via Suppressing NISCH Expression

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Hailin;Xie, Wei;Liu, Ying;Zhang, Bocheng;Peng, Mingjing;...

通讯作者：

Long, Y

作者机构：

[Long, Ying; Zhang, Bocheng; Peng, Mingjing; Dai, Jie; Long, Y; Zhang, Hailin; Zhou, Xiao] Cent South Univ, Translat Med Ctr, Hunan Canc Hosp, Affiliated Canc Hosp, Changsha 410013, Hunan, Peoples R China.

[Long, Ying; Sheng, Xiaowu; Zhang, Bocheng; Luo, Chenhui; Peng, Mingjing; Dai, Jie; Ren, Huayi; Li, Zan; Long, Y; Gong, Qian; Xie, Wei; Li, Sha; Zhang, Hailin; Zhou, Xiao] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.

[Long, Ying; Sheng, Xiaowu; Zhang, Bocheng; Luo, Chenhui; Peng, Mingjing; Dai, Jie; Li, Zan; Long, Y; Xie, Wei; Li, Sha; Zhang, Hailin; Zhou, Xiao] Cent South Univ, Hunan Prov Clin Res Ctr Oncoplast Surg, Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China.

[Zhang, Bocheng; Dai, Jie; Li, Zan; Li, Sha; Zhang, Hailin; Zhou, Xiao] Cent South Univ, Dept Head & Neck Surg, Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China.

[Xie, Wei] Cent South Univ, Dept Hepatobiliary Surg, Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Long, Y ] C

Cent South Univ, Translat Med Ctr, Hunan Canc Hosp, Affiliated Canc Hosp, Changsha 410013, Hunan, Peoples R China.

Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.

Cent South Univ, Hunan Prov Clin Res Ctr Oncoplast Surg, Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China.

Cent South Univ, Hunan Prov Clin Res Ctr Wound Rehabil, Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

5 ethynyl 2' deoxyuridine;cell cycle protein;deoxyuridine derivative;microRNA;microRNA 2355 5p;nischarin;small interfering RNA;tumor suppressor protein;unclassified drug;3' untranslated region;Article;binding site;bioinformatics;cancer growth;cancer tissue;cell cycle progression;cell proliferation;chemoluminescence;controlled study;flow cytometry;G1 phase cell cycle checkpoint;gene expression level;gene expression regulation;gene function;gene repression;gene targeting;genetic transfection;head and neck squamous cell carcinoma;head and neck squamous cell carcinoma cell line;human;human cell;human tissue;luciferase assay;NISCH gene;protein expression level;real time polymerase chain reaction;RNA binding;RNA pull-down;S phase cell cycle checkpoint;tumor suppressor gene;upregulation;Western blotting

期刊：

Journal of Oncology

ISSN：

1687-8450

年：

2021

卷：

2021

页码：

1-11

DOI：

10.1155/2021/2986489

基金类别：

National Natural Science Foundation of China [81703005, 81902794]; Natural Science Foundation of Hunan Province [2017JJ3195, 2018JJ3317, 2021JJ30427]; Hunan Provincial Science and Technology Department [2018SK2120, 2018SK2122, 2018SK50907, 2018SK7005]; Scientific Research Project of Hunan Provincial Health Commission [B2013-097, B2019092, C2019080, 20201650, 20201653, 202102082037]; Changsha Science and Technology Bureau Foundation [kq1706044, kq1901074]; Key Clinical Specialty Construction Project (Head & Neck Surgery) of the Provincial Health Commission of Hunan Province

机构署名：

本校为其他机构

摘要：

Background. MicroRNAs (miRNAs) have emerged as crucial regulators in various cancers. However, the potential role of miR-2355-5p in head and neck squamous cell carcinoma (HNSC) remains unclear. Methods. Bioinformatics methods were implemented to find the candidate target gene of miR-2355-5p. Quantitative real-time PCR was performed to detect RNA expression levels of miR-2355-5p and NISCH, while western blot was carried out for the detection of protein levels of NISCH and cell cycle-related biomarkers. CCK-8, EdU staining, and flow cytometry wer...

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MicroRNA-2355-5p Promotes the Proliferation of Head and Neck Squamous Cell Carcinoma via Suppressing NISCH Expression

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