期刊论文

BYHWD on Focal Cerebral Ischemia in Rats and vWF of BrdU

中文

医学信息

1006-1959

2013

17

168-169

10.3969/j.issn.1006-1959.2013.17.205

广州市中医药科技项目

本校为第一机构

目的探讨补阳还五汤对局灶性脑缺血大鼠BrdU及vWF的影响。方法采用大脑中动脉线栓法建立右侧局灶性脑缺血大鼠模型,将动物随机分为正常组、假手术组、模型组、补阳还五汤组,腹腔注射Brdu,分别于1d、7d、14d和28d处死动物,采用免疫组织化学法观察 BrdU及 vWF的表达。结果正常脑内存在一定的BrdU及vWF阳性细胞,脑缺血后表达迅速增加,7d达高峰,然后逐渐下降；补阳还五汤可显著增强 BrdU及 vWF的表达,在第7d、14d时明显多于其它各组（P

Objective:To explore the ef ect of Buyang Huanwu Decoction (BYHWD)on BrdU and vWF in rats after focal cerebral ischemia. Methods:The model of focal cerebral ischemia in rats was reproduced by middle cerebral artery occlusion.Rats were randomly divided into fol owing groups including navie,shame-operated,ischemia and Buyang Huanwu Decoction (BYHWD) groups. Animals were received BrdU-labeled and kil ed at 1,7,14 and 28 day point after operation.BrdU and vWF were measured by immunohistochemical staining. Result:There was a certain BrdU or vWF positive cel s in normal brain, after cerebral ischemi...