NEK2 overexpression aggravates IL-22-induced keratinocyte proliferation and cytokine level increases and IMQ-induced psoriasis-like dermatitis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Peng, Youhua;Zhang, Yujin;Luo, Meijunzi;Pan, Yi;Zhou, Rong;...

通讯作者：

Wang, HZ

作者机构：

[Wang, Li; Yi, Tingting; Zhou, Rong; Zhang, Yujin; Wang, Haizhen; Luo, Feifei; Ran, Chongjun; Luo, Meijunzi; Yan, Yi-ning; Peng, Youhua; Wang, HZ; Pan, Yi; Wang, Biying] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Dermatol, Domest First Class Discipline Construct Project, Changsha 410005, Hunan, Peoples R China.

[Peng, Youhua] Hunan Aerosp Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China.

通讯机构：

[Wang, HZ ] H

Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Dermatol, Domest First Class Discipline Construct Project, Changsha 410005, Hunan, Peoples R China.

语种：

英文

关键词：

Inflammation;Keratinocytes;NEK2;Psoriasis;The STAT3 signaling

期刊：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ISSN：

0167-4889

年：

2023

卷：

1870

期：

页码：

119525

DOI：

10.1016/j.bbamcr.2023.119525

基金类别：

National Natural Science Foundation of China [82004381]; Natural Science Foundation of Hunan Province, China [2020JJ5431, 2021JJ40412, 2021JJ40414]; Hunan Provincial Scientific Research Program of Traditional Chinese Medicine [C2022025]; Scientific Research Project of Hunan Provincial Health Commission [20201213]; Hunan Provincial Traditional Chinese Medicine Research Program Youth Project [2021187]; Hunan Provincial Traditional Chinese Medicine First-class Open Fund Project [2022ZYX05]; Hunan University of Chinese Medicine Research Program [2022YYZK007]

机构署名：

本校为第一且通讯机构

院系归属：

第二中医临床医学院

摘要：

BACKGROUND: Psoriasis is a common inflammatory skin disease characterized by the excessive proliferation and abnormal differentiation of keratinocytes. Protein kinases could act on intracellular signaling pathways associated with cell proliferation. OBJECTIVE: Identifying more hub protein kinases affecting cellular and molecular processes in psoriasis, and exploring the dynamic effects of baicalin and NEK2 on the IL-22-induced cellular inflammation and IMQ-induced psoriasis-like mice. METHODS AND RESULTS: In this study, differentially expressed protein kinases playing a hub role in psoriasis i...

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NEK2 overexpression aggravates IL-22-induced keratinocyte proliferation and cytokine level increases and IMQ-induced psoriasis-like dermatitis

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