Oxidative stress and antioxidant defense in detoxification systems of snake venom-induced toxicity

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成果类型：

期刊论文

作者：

Dong, Degang;Deng, Zhongping;Yan, Zhangren;Mao, Wenli;Yi, Jun;...

通讯作者：

Wang, WC

作者机构：

[Dong, Degang] Jiangxi Univ Tradit Chinese Med, Sch Life Sci, Nanchang, Jiangxi, Peoples R China.

[Deng, Zhongping; Dong, Degang] Shanghai Univ Chinese Med, Innovat Chinese Med Res Inst, Shanghai, Peoples R China.

[Mao, Wenli; Liu, Liang; Chen, Jun; Chen, Qi; Yan, Zhangren; Yi, Jun; Li, Qiang; Wang, Wanchun; Huang, Xiuqin; Wang, Xi] Jiangxi Univ Tradit Chinese Med, Southern Snake Bite Control Ctr, Affiliated Hosp, Nanchang, Jiangxi, Peoples R China.

[Song, Mei] Jiangxi Univ Tradit Chinese Med, Sci & Technol Coll, Nanchang, Jiangxi, Peoples R China.

[Song, Mei] Hunan Univ Chinese Med, Coll Chinese Med, Changsha, Peoples R China.

通讯机构：

[Wang, WC ] J

Jiangxi Univ Tradit Chinese Med, Southern Snake Bite Control Ctr, Affiliated Hosp, Nanchang, Jiangxi, Peoples R China.

语种：

英文

关键词：

snake venom;somatomedin;antioxidant activity;Article;catabolism;clinical article;controlled study;Deinagkistrodon acutus;detoxification;human;innate immunity;lipid metabolism;liquid chromatography-mass spectrometry;Naja;nonhuman;oxidative stress;oxygen transport;patient selection;polyacrylamide gel electrophoresis;protein analysis;protein expression;proteomics;snakebite;Trimeresurus;Trimeresurus stejnegeri;Vipera

期刊：

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

ISSN：

1678-9180

年：

2021

卷：

页码：

e20200053

DOI：

10.1590/1678-9199-JVATITD-2020-0053

基金类别：

This work was supported by grants from the Natural Science Foundation (81960874, 81360288), the Natural Science Foundation of Jiangxi (20181BAB205074, 20202ACB206010), the Double First-Class Construction Project of Jiangxi Province (JXSYLXK-ZHYI054), and Science and Technology Project of the Education Department of Jiangxi Province (GJ60811). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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本校为其他机构

摘要：

Background: Snakebites remain a major life-threatening event worldwide. It is still difficult to make a positive identification of snake species by clinicians in both Western medicine and Chinese medicine. The main reason for this is a shortage of diagnostic biomarkers and lack of knowledge about pathways of venom-induced toxicity. In traditional Chinese medicine, snakebites are considered to be treated with wind, fire, and wind-fire toxin, but additional studies are required. Methods: Cases of snakebite seen at the Affiliated Hospital of Jiang...

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Oxidative stress and antioxidant defense in detoxification systems of snake venom-induced toxicity

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