Melanin-concentrating hormone: A promising target for antidepressant treatment

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成果类型：

期刊论文

作者：

Shi, Lingchang;He, Ying;Lian, Yujun;Luo, Jie;Zhu, Xuan*;...

通讯作者：

Zhu, Xuan;Zhao, HQ

作者机构：

[Shi, Lingchang] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.

[He, Ying; Zhao, Hongqing] Hunan Univ Chinese Med, Sci & Technol Innovat Ctr, Changsha 410208, Hunan, Peoples R China.

[Zhu, Xuan; He, Ying; Zhao, Hongqing; Zhu, X] Hunan Key Lab Tradit Chinese Med Prevent & Treatme, Changsha 410208, Hunan, Peoples R China.

[Lian, Yujun] Hunan Univ Chinese Med, Sch Nursing, Changsha 410208, Hunan, Peoples R China.

[Luo, Jie] Hunan Univ Chinese Med, Coll Acupuncture Massage & Rehabil, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Zhao, HQ ; Zhu, X] H

Hunan Key Lab Tradit Chinese Med Prevent & Treatme, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Antidepressant;Depression;Melanin-concentrating hormone;Melanin-concentrating hormone receptor 1;Neuropeptide;Sleep-wake cycle

期刊：

Pharmacology Biochemistry and Behavior

ISSN：

0091-3057

年：

2025

卷：

250

页码：

173999

DOI：

10.1016/j.pbb.2025.173999

基金类别：

CRediT authorship contribution statement Lingchang Shi: Writing – original draft, Conceptualization. Ying He: Writing – original draft, Visualization, acquisition. Yujun Lian: Supervision, Conceptualization. Jie Luo: Visualization. Xuan Zhu: Supervision, acquisition, Conceptualization. Hongqing Zhao: Writing – review & editing, Visualization, acquisition, Conceptualization. This work was supported by National Natural Science Foundation of China (No. 82104836 ), Natural Science Foundation of Changsha City (No. kq2402182 ), Scientific Research Project of Hunan Province Education Department (No. 23B0391 ), Innovation Project for College Students in Hunan Province (No. S202410541029 ) and Science & Technology talent promotion Project of Hunan Province (No. 2023TJ-N22 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

针灸推拿与康复学院

护理学院

摘要：

Depression represents a complex neuropsychiatric disorder with an escalating global health burden, characterized by heterogeneous pathophysiology and profound impairments in cognitive-emotional functioning. Current treatment methods have limited efficacy in some individuals and may induce undesirable side effects, necessitating the exploration of novel therapeutic targets and techniques. Emerging research has identified neuropeptide systems as pivotal regulators of mood-related circuits, with melanin-concentrating hormone (MCH) signaling emerging as a particularly promising candidate for antid...

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