Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Yingchen;Cheng, Qilai;Hu, Guoheng;Deng, Tianhao;Wang, Qimei;...

通讯作者：

Zhou, JD;Su, XP

作者机构：

[Li, Yingchen] Cent S Univ, Xiangya Hosp 3, Postdoctoral Res Stn Clin Med, Changsha 410013, Hunan, Peoples R China.

[Cheng, Qilai] Gannan Med Univ, Coll Pharm, Ganzhou 341000, Jiangxi, Peoples R China.

[Hu, Guoheng] Hunan Univ Tradit Chinese Med, Dept Neurol, Affiliated Hosp 1, Changsha 410007, Hunan, Peoples R China.

[Wang, Qimei; Deng, Tianhao] Hunan Inst Tradit Chinese Med, Dept Oncol, Affiliated Hosp, Changsha 410006, Hunan, Peoples R China.

[Zhou, Jianda] Cent S Univ, Xiangya Hosp 3, Dept Plast Surg, 138 Tongzhipo Rd, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Zhou, JD ] C

[Su, XP ] H

Cent S Univ, Xiangya Hosp 3, Dept Plast Surg, 138 Tongzhipo Rd, Changsha 410013, Hunan, Peoples R China.

Hunan Inst Tradit Chinese Med, Dept Osteol, Affiliated Hosp, 58 Lushan Rd, Changsha 410006, Hunan, Peoples R China.

语种：

英文

关键词：

exosomes;extracellular vesicles;mesenchymal stromal cells;microvesicles;stroke

期刊：

EXPERIMENTAL AND THERAPEUTIC MEDICINE

ISSN：

1792-0981

年：

2018

卷：

期：

页码：

4067-4079

DOI：

10.3892/etm.2018.5993

基金类别：

National Natural Science Foundation of China [81273751, 81372140, 81360627, 81572689, 81573941]; China Postdoctoral Science Foundation [2017M610509]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

A stroke is a focal cerebral insult that frequently causes severe neurological deficit and mortality. Recent studies have demonstrated that multipotent mesenchymal stromal cells (MSCs) hold great promise for neurovascular remodeling and neurological function recovery following a stroke. Rather than a direct replacement of parenchymal brain cells, the therapeutic mechanism of MSCs is suggested to be the secretion of soluble factors. Specifically, emerging data described MSCs as being able to release extracellular vesicles (EVs), which contain a ...

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Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)

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