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CTNNBIP1 modulates keratinocyte proliferation through promoting the transcription of β-catenin/TCF complex downstream genes

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成果类型:
期刊论文
作者:
Wang, C.;Wang, H.;Peng, Y.;Zeng, B.;Zhang, Y.;...
通讯作者:
Yang, Z
作者机构:
[Zeng, B.; Yang, Z; Mi, L.; Yang, Z.; Tang, X.; Wang, C.; Wang, H.; Pan, Y.; Peng, Y.; Zhang, Y.] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Dermatol, Domest Class Discipline Construct Project Chinese, Changsha, Hunan, Peoples R China.
通讯机构:
[Yang, Z ] H
Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Dermatol, Domest Class Discipline Construct Project Chinese, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
adalimumab;beta catenin;catenin beta interacting protein 1;cyclin D1;imiquimod;Ki 67 antigen;messenger RNA;methotrexate;Myc protein;T cell factor protein;transcription factor 4;unclassified drug;beta catenin;CTNNBIP1 protein, human;signal transducing adaptor protein;antigen expression;apoptosis;Article;cell nucleus;cell proliferation;clinical article;controlled study;disease course;disease exacerbation;down regulation;experimental study;flow cytometry;gene expression profiling;genetic association;genetic transcription;HaCat cell line;human;human cell;human tissue;immortalized cell line;immunoblotting;immunofluorescence assay;intracellular transport;keratinocyte;luciferase assay;molecular pathology;MTT assay;online analysis;phenotype;protein binding;protein defect;protein expression;protein function;protein microarray;protein protein interaction;protein transport;psoriasis;real time polymerase chain reaction;RNA sequencing;skin defect;tissue section;upregulation;animal;apoptosis;cell proliferation;genetics;keratinocyte;metabolism;mouse;Adaptor Proteins, Signal Transducing;Animals;Apoptosis;beta Catenin;Cell Nucleus;Cell Proliferation;Humans;Keratinocytes;Mice
期刊:
Journal of the European Academy of Dermatology and Venereology
ISSN:
0926-9959
年:
2021
卷:
35
期:
2
页码:
368-379
基金类别:
This study was supported by the National Natural Science Foundation of China (81573985 and 81774326) and Natural Science Foundation of Hunan Province (2017JJ2207).
机构署名:
本校为其他机构
院系归属:
第二中医临床医学院
摘要:
Background: During psoriasis initiation and development, deregulations in signalling pathways and gene expression are observed. Methods: Herein, we downloaded seven sets of microarray mRNA expression profiles showing differentially expressed genes in psoriasis lesion skin and non-lesion skin tissues and three sets of RNA-seq data and analysed these online data attempting to screen for crucial genes related to keratinocyte proliferation and psoriasis development. The expression of CTNNBIP1 in psoriasis patients and IMQ mouse model skin tissues w...

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