Xiebai Zengye decoction improves respiratory function and attenuates inflammation in juvenile rats with postinfection cough via regulating ERK signaling pathway

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成果类型：

期刊论文

作者：

Luo, Jing;Deng, Yijue;Ding, Yi;Tang, Chenguang;Wang, Mengqing

通讯作者：

Tang, CG;Wang, MQ

作者机构：

[Tang, Chenguang; Luo, Jing] Shenzhen Qianhai Shekou Free Trade Zone Hosp, Dept Tradit Chinese Med, Shenzhen, Peoples R China.

[Deng, Yijue; Wang, MQ; Wang, Mengqing; Luo, Jing] Hunan Univ Chinese Med, Hosp 1, Dept Paediat, Changsha, Peoples R China.

[Ding, Yi] Changsha Social Work Coll, Sch Rehabil, Changsha, Peoples R China.

通讯机构：

[Tang, CG ] S

[Wang, MQ ] H

Shenzhen Qianhai Shekou Free Trade Zone Hosp, Dept Tradit Chinese Med, Shenzhen, Peoples R China.

Hunan Univ Chinese Med, Hosp 1, Dept Paediat, Changsha, Peoples R China.

语种：

英文

关键词：

EKR signaling;Xie Bai Zeng Ye decoction;cytokine;montelukast sodium;postinfectious cough;respiratory function

期刊：

Cell Biochemistry and Function

ISSN：

0263-6484

年：

2023

卷：

期：

页码：

857-867

DOI：

10.1002/cbf.3835

基金类别：

National Natural Science Foundation of China [81774368]; Shenzhen Nanshan District Education (Health) Science and Technology Project [NS2023061]; Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine [4901-020000200207]; Shenzhen Key Discipline Construction Funding Project of Traditional Chinese Medicine

机构署名：

本校为通讯机构

院系归属：

第一中医临床学院

摘要：

This study aimed to determine the effects of Xiebai Zengye decoction (XBZY)on airway inflammation and respiratory function in rats with postinfectious cough (PIC),and its regulatory effects on the extracellular signal-regulated kinase (ERK)signaling pathway. Compared with the normal group, the rats from thePIC group had significantly shortened expiratory time (TE)and enhanced pause (EEP),increased resistance (RT),and enhanced pause (Penh), along with increased levels of serum interleukin-4 (IL-4)and IL-6,and decreased levels of IL-10. The lung and colon tissues of rats from the PIC group showe...

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Xiebai Zengye decoction improves respiratory function and attenuates inflammation in juvenile rats with postinfection cough via regulating ERK signaling pathway

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