A facile access to thieno[2,3-b]indoles via sulfur-mediated decarboxylative cyclization of α, β-unsaturated carboxylic acids with indoles

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成果类型：

期刊论文

作者：

Zhang, Hao-Lin;Wen, Fei;Sheng, Wen-Bing;Yin, Peng;Zhang, Chun-Tao;...

通讯作者：

Fu, Rong-Geng

作者机构：

[Fu, Rong-Geng; Sheng, Wen-Bing; Peng, Dong-Ming; Zhang, Chun-Tao; Peng, Cai-Yun; Wen, Fei; Liao, Duan-Fang; Zhang, Hao-Lin] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

[Fu, Rong-Geng; Liao, Duan-Fang] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China.

[Fu, Rong-Geng] Hunan Key Lab Druggabil & Preparat Modificat Trad, Changsha 410208, Hunan, Peoples R China.

[Yin, Peng] Hunan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Hunan, Peoples R China.

通讯机构：

[Fu, Rong-Geng] H

Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Thieno[2,3-b]indoles;Sulfur-mediated;Decarboxylation;Cyclization;Three-component reaction

期刊：

Tetrahedron Letters

ISSN：

0040-4039

年：

2019

卷：

期：

页码：

80-83

DOI：

10.1016/j.tetlet.2018.11.062

基金类别：

Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2015JJ6085]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [13B080, 17C1192]; Special Fund for International Cooperation of Chinese Medicine [ZYGZ201502]; Research Fund of the Pharmaceutical Science Key Discipline in the Hunan Province; College Students' Research Learning and Innovative Experiment Plan Project of Hunan University of Chinese Medicine [201842]

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

An efficient synthesis of thieno[2,3-b]indoles via a one-pot three-component reaction was well established. By using inexpensive and commercial available indoles and a, a-unsaturated carboxylic acids in the presence of elemental sulfur, various functional groups were achieved in moderate to good yields. (C)...

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A facile access to thieno[2,3-b]indoles via sulfur-mediated decarboxylative cyclization of α, β-unsaturated carboxylic acids with indoles

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