Alzheimer's disease(AD) is an age-related and very fatal neurodegenerative disease,with learning,memory and cognition dysfunction as prominent features,and its etiology is not clear and the pathogenesis is complex.AD brings huge burden to the society,but it is still lack of effective treatment measures.The lag of animal models restricts the screen-ing of therapeutic drugs.In recent years,with the growing maturity of transgenic animal technology,a variety of AD animal models have emerged in succession.At present,the AD gene engineering mouse models include single genetically modified models,dou...
