期刊论文

中文

医学综述

1006-2084

2019

25

4

659-664+670

10.3969/j.issn.1006-2084.2019.04.007

湖南省科技计划项目(2017SK4005).

本校为第一机构

线粒体自噬是一种控制线粒体数量的选择性自噬过程,其对维持细胞正常表型和功能至关重要,且与心脑血管疾病（神经退行性疾病、缺血性脑卒中、心力衰竭等）密切相关。脑缺血再灌注损伤是指缺血脑组织在梗死相关血管开通后,可能导致比血管闭塞时更严重的急性损伤。而线粒体自噬与脑缺血再灌注损伤密切相关,其与氧化应激、线粒体动力学等有关。而这些过程受线粒体自噬相关蛋白（第10号染色体缺失的磷酸酶和张力蛋白同源物诱导的假定激酶1、Parkin、Bcl-2/腺病毒E1B 19 k Da相互作用蛋白3等）的调控。适度的线粒体自噬对细胞具有保护作用,从而减轻脑缺血再灌注损伤;但线粒体自噬功能受损清除不足或过...

Mitochondrial autophagy is a selective autophagy process that controls the number of mitochondria and is essential for maintaining normal phenotype and function of cells.Also,it is closely related to cardio-cerebrovascular diseases such as neurodegenerative diseases,ischemic stroke,heart failure and so on.Cerebral ischemia reperfusion injury refers to the acute injury of ischemic brain tissue that may cause more severe damage than vascular occlusion after infarct-related blood vessel opening.Mitochondrial autophagy is closely related to cerebral ischemia reperfusion injury,which is related to ...