期刊论文

Research Progress in Disease and Non-disease Risk Factors and Pathogenesis of Vascular Dementia

中文

医学综述

1006-2084

2022

28

14

2821-2826

10.3969/j.issn.1006-2084.2022.14.020

18B232:湖南省教育厅科学研究项目 201493:湖南省中医药科研计划项目 2018XJJJ05:湖南中医药大学校级科研基金项目

本校为第一机构

除各类疾病因素（脑血管疾病、系统性自身免疫疾病、慢性牙周炎、2型糖尿病、睡眠呼吸障碍等）外，血管性痴呆（VD）的相关危险因素还涉及部分非疾病因素，主要为基因、肥胖、体育活动等。而目前VD发病机制的主要研究对象为神经元、神经胶质细胞及周围血管，全面涵盖了机体意识思维发挥生理作用的结构，相关结果主要集中于神经细胞自噬机制、基因沉默、核因子κB信号通路、脑灰质萎缩等领域。但VD的确切发病机制尚不清楚，仍有待进一探究。

In addition to various disease factors(cerebrovascular disease,systemic autoimmune disease,chronic periodontitis,type 2 diabetes mellitus,sleep disordered breathing,etc.),the related risk factors of vascular dementia(VD)also involve some non-disease factors,mainly genes,obesity,sports activities,etc.At present,the main research objects of the pathogenesis of VD are neurons,glial cells and peripheral blood vessels,comprehensively covering the structure of the physiological function of the body′s conscious thinking.The relevant results mainly fo...