Astragaloside IV Relieves Mitochondrial Oxidative Stress Damage and Dysfunction in Diabetic Mice Endothelial Progenitor Cells by Regulating the GSK-3β/Nrf2 Axis.

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成果类型：

期刊论文

作者：

Xiaoling Zou;Xiangnan Liu;Wenjing Qu;Xi Zhang;Yixian Zou;...

通讯作者：

Wu Xiong

作者机构：

[Xiaoling Zou; Yixian Zou; Xiangdong Lin; Wenxiao Hu] Department of Endocrinology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China

[Xiangnan Liu; Wenjing Qu; Ruchun Gao; Youyuan He] The First Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China

[Xi Zhang] Hunan Brain Hospital, Clinical Medical School of Hunan University of Chinese Medicine, Changsha, China

[Siyuan Zhou; Yuxuan Huang] College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China

[Wu Xiong] Department of Breast Surgery, The First Hospital of Hunan University of Chinese Medicine, Changsha, China

通讯机构：

[Wu Xiong] D

Department of Breast Surgery, The First Hospital of Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Astragaloside IV;Diabetes mellitus;Endothelial progenitor cell;GSK-3β/Nrf2;Mitochondrial dysfunction;Oxidative damage

期刊：

Molecular Biotechnology

ISSN：

1073-6085

年：

2025

页码：

1-18

DOI：

10.1007/s12010-025-05211-6

基金类别：

This work was supported by the Natural Science Foundation of Changsha (No.2502258), the Science and Health Joint Project of Hunan Natural Science Foundation (No. 2021JJ70033), the Innovation and Entrepreneurship Training Program for College students in Hunan Province Innovation Training Program (No. S202310541040), the National Natural Science Foundation of China (No. 82374276), and the Clinical Medical Technology Innovation Guidance Project of Hunan Provincial Science and Technology Department (No. 2021SK51412), the Medical and Health Joint Project of Hunan Natural Science Foundation (No. 2025JJ80930).

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

摘要：

Dysregulation of mitochondrial activity is a major cause of diabetes mellitus (DM) and its complications. Astragaloside IV, a natural herbal product, possesses protective properties against DM. This study aimed to evaluate how astragaloside IV affects oxidative stress and mitochondrial function in endothelial progenitor cells (EPCs) and elucidate the underlying mechanisms. A high glucose (HG)-induced human EPC (hEPC) model and a streptozotocin (STZ)-induced DM mouse model were established to investigate the effects of astragaloside IV on EPC fu...

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Astragaloside IV Relieves Mitochondrial Oxidative Stress Damage and Dysfunction in Diabetic Mice Endothelial Progenitor Cells by Regulating the GSK-3β/Nrf2 Axis.

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