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Knockdown of Long Non-coding RNA SNGH3 by CRISPR-dCas9 Inhibits the Progression of Bladder Cancer

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成果类型:
期刊论文
作者:
Cao, Yu;Hu, Qiong;Zhang, Ruiming;Li, Ling;Guo, Mingjuan;...
通讯作者:
Li, C.;Zhang, L.;Wang, J.
作者机构:
[Hu, Qiong; Zhang, Ruiming; Cao, Yu] Hunan Univ Tradit Chinese Med, Ningxiang Hosp, Ningxiang, Peoples R China.
[Li, Ling] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Med Basic Teaching Expt Ctr, Changsha, Peoples R China.
[Wei, Huiling; Li, Chunjing; Zhang, Li; Guo, Mingjuan; Wang, Jianfeng] Southern Med Univ, Affiliated Foshan Maternal & Child Healthcare Hos, Dept Urol, Foshan, Peoples R China.
通讯机构:
[Zhang, L.; Wang, J.; Li, C.] D
Department of Urology, China
语种:
英文
关键词:
SNGH3;Bladder cancer;CRISPR-dCas9;lncRNA;Therapeutic target
期刊:
Frontiers in Molecular Biosciences
ISSN:
2296-889X
年:
2021
卷:
8
页码:
657145
基金类别:
This work was supported by the Guangdong Provincial Medical Science and Technology Research Funding (No. 20205792148508), the Changsha Science and Technology Bureau project (No. kq1907033), the National Nature Science Foundation of China (No. 81703919), and the Hunan Natural Science Foundation (No. 2020JJ5418).
机构署名:
本校为第一机构
院系归属:
中医学院
摘要:
Recent research evidence documents that lncRNAs (long non-coding RNAs lncRNAs) play a pivotal role in the tumorigenesis and development of tumors. LncRNA SNGH3 (small nucleolar RNA host gene 3) is highly expressed in numerous forms of cancer, serving as an oncogene in cancer progression. Nonetheless, the clinical relationship, along with the mechanism of SNGH3 in bladder cancer, have not been studied. Herein, the findings exhibited upregulation of SNGH3 in bladder cancer tissues, along with the cell lines. Furthermore, overexpressed SNGH3 was positively linked to the TNM stage, as well as the ...

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