Integrated pyroptosis measurement and metabolomics to elucidate the effect and mechanism of tangzhiqing on atherosclerosis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Rui;Chen, Ting;Zhou, Zhihuan;Song, Zhihui;Feng, Wanying;...

作者机构：

[Zhou, Zhihuan; Chen, Rui] Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin, Peoples R China.

[Chen, Ting] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Peoples R China.

[Yang, Xintong; Wang, Yi; Ding, Xinya; Zhang, Han; Song, Zhihui; Feng, Wanying] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin, Peoples R China.

[Li, Bin; Wang, Xianliang] Tianjin Univ Tradit Chinese Med, Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Teaching Hosp 1, Tianjin, Peoples R China.

[Zhang, Han] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin, Peoples R China.

语种：

英文

关键词：

Tangzhiqing;Inflammasomes;pyroptosis;Atherosclerosis;Chinese traditional medicine

期刊：

Frontiers in Physiology

ISSN：

1664-042X

年：

2022

卷：

页码：

937737

DOI：

10.3389/fphys.2022.937737

基金类别：

This work was supported by the Graduate Research Innovation Project of Tianjin University of Traditional Chinese Medicine (Grant number: YJSKC-20191001), Graduate Research Innovation Project of Tianjin (Grant number: JJ1901010302) and Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine. (Grant number: ZYYCXTD-C-202203).

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摘要：

Tangzhiqing formula (TZQ) is a traditional Chinese medicine prescribed to treat glucose and lipid metabolism disorders. A significant effect of TZQ on diabetes and hyperlipidemia has been demonstrated, but its effect on atherosclerosis (AS) remains unknown. This study combines pyroptosis with metabolomics to elucidate the effect and mechanism of TZQ on AS. A model of AS was developed using ApoE(-/-) mice fed a high-fat diet for 8 weeks. After 6 weeks of atorvastatin (Ator) or TZQ treatment, aortic lumen diameter, aortic lesion size, serum lipid profile, cytokines, and Nod-like receptor protein...

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Integrated pyroptosis measurement and metabolomics to elucidate the effect and mechanism of tangzhiqing on atherosclerosis

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