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Leonurine promotes neurite outgrowth and neurotrophic activity by modulating the GR/SGK1 signaling pathway in cultured PC12 cells

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成果类型:
期刊论文
作者:
Meng, Pan;Zhu, Qing;Yang, Hui;Liu, Dan;Lin, Xiaoyuan;...
通讯作者:
Wang, Yuhong;Cai, X
作者机构:
[Meng, Pan; Cai, Xiong; Cai, X; Wang, Yuhong; Zhu, Qing; Su, Wei; Wang, YH; Liu, Xiaodan; Fan, Jingying] Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, 300 Xueshi Rd,Hanpu Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.
[Lin, Xiaoyuan; Yang, Hui; Liu, Dan; Liu, Lin; Liu, Jian] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.
[Zhu, Qing] Cent S Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha, Hunan, Peoples R China.
通讯机构:
[Wang, YH; Cai, X ] H
Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, 300 Xueshi Rd,Hanpu Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
brain derived neurotrophic factor;corticosterone;fluoxetine;glucocorticoid receptor;leonurine;mifepristone;neurotrophic factor;neurotrophic factor 3;protein bcl 2;serum and glucocorticoid regulated kinase 1;unclassified drug;antidepressant agent;gallic acid;glucocorticoid receptor;immediate early protein;leonurine;protein serine threonine kinase;serum-glucocorticoid regulated kinase;animal cell;antidepressant activity;Article;cell death;cell maturation;cell viability;controlled study;drug mechanism;MTT assay;nerve cell differentiation;neurite outgrowth;neurotropism;nonhuman;PC12 cell line (pheochromocytoma);priority journal;rat;signal transduction;animal;cell survival;drug effect;metabolism;neurite outgrowth;PC12 cell line;signal transduction;Animals;Antidepressive Agents;Cell Survival;Gallic Acid;Immediate-Early Proteins;Neuronal Outgrowth;PC12 Cells;Protein-Serine-Threonine Kinases;Rats;Receptors, Glucocorticoid;Signal Transduction
期刊:
NEUROREPORT
ISSN:
0959-4965
年:
2019
卷:
30
期:
4
页码:
247-254
基金类别:
This study was financially supported by grants from the National Natural Science Foundation of Hunan (2018JJ3388, 2017JJ3235), National Natural Science Foundation of China (81403387) and the Provincial Department of education innovation platform open fund project of Hunan (16K067,17B201). Also, it was supported by the domestic first class construction discipline of Chinese Medicine in Hunan University of Chinese Medicine.
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
摘要:
Depression is a common psychiatric disorder that affects almost 10% of children and adolescents worldwide. Numerous synthetic chemical antidepressants used to treat depression have adverse side effects. Therefore, new therapeutic approaches for depression treatment are urgently needed. Leonurus cardiaca has recently been shown to be effective for the treatment of nervous system diseases such as depression, but its mechanism is not clear. In this study, we aimed to reveal the mechanism underlying leonurine’s antidepressant activity. Leonurine w...

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