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Prevention of streptozotocin-induced diabetic nephropathy by the lupanetype triterpene isolated from the leaves of Acanthopanax gracilistylus

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成果类型:
期刊论文
作者:
Yang, Yang;Luo, Jiao;Lu, Man-Xia;Zhang, Hong-Chi;An, Zhi-Peng;...
通讯作者:
Liu, Xiang-Qian;Hwang, Eun-Hee
作者机构:
[Zhang, Hong-Chi; An, Zhi-Peng; Yang, Yang] Shanxi Datong Univ, Sch Life Sci, Datong, Peoples R China.
[Lu, Man-Xia; Liu, Xiang-Qian; Luo, Jiao] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.
[Hwang, Eun-Hee] Wonkwang Univ, Dept Food & Nutr, Iksan 54538, South Korea.
通讯机构:
[Liu, Xiang-Qian] H
[Hwang, Eun-Hee] W
Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.
Wonkwang Univ, Dept Food & Nutr, Iksan 54538, South Korea.
语种:
英文
关键词:
Diabetes mellitus;Diabetic neuropathy;Kidney;Streptozotocin
期刊:
Acta Medica Mediterranea
ISSN:
0393-6384
年:
2020
卷:
36
期:
1
页码:
517-522
基金类别:
Wonkwang University
机构署名:
本校为通讯机构
院系归属:
药学院
摘要:
Acanthopanax gracilistylus is traditionally used to treat bone pains, arthritis, and rheumatism by the rook bark. To evaluate the renoprotective effect of the acankoreagenin, from the leaves of Acanthopanax gracilistylus (LAG), glucose loaded and streptozotocin (STZ) induced diabetic rats. The diabetic nephropathy (DN) rats were induced with STZ (70 mg/kg) by a single intraperitoneal injection. The acankoreagenin, was administered orally to normal and diabetic rats with guava extract and solvent control as comparison groups. Long term effects l...

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