期刊论文

Efficacy and safety of edaravone combined with Shuxuetong Injection in treatment of acute cerebral infarction rats

中文

中华中医药杂志

1673-1727

2017

32

9

4243-4248

湖南省科技厅重点项目（No.2014SK2007）~~；

本校为第一机构

目的:评价依达拉奉联合疏血通注射液治疗急性脑梗死大鼠的疗效和安全性。方法:将SD大鼠随机分为:假手术组、模型组、依达拉奉组、疏血通组、依达拉奉联合疏血通组,采用线栓法复制大鼠左侧大脑中动脉脑缺血(middle cerebral artery occlusion,MCAO)模型,除假手术组外,每组按不同时间点(1、3、5、7d)分为4个亚组,术后各组腹腔注射相应药物,1次/d,连续给药1、3、5、7d,模型组、假手术组分别予以等体积0.9%氯化钠溶液,观察比较各组大鼠神经功能缺损评分、脑组织梗死体积、脑组织含水量、脑组织形态学改变及白细胞计数(WBC)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酐(Cr)、尿素氮(BUN)、磷酸肌酸激酶...

Objective: To evaluate the efficacy and safety of edaravone combined with Shuxuetong Injection in the treatment of acute cerebral infarction rats. Methods: SD rats were randomly divided into sham operation group, model group. edaravone group, shuxuetong group and edaravone combined with shuxuetong group. The left middle cerebral artery cerebral ischemia (MCAO) model was established by using suture method. Except for sham operation group, each group was divided into 4 subgroups according to different time points (1, 3, 5, 7d). The rats in each group were injected intraperitoneally with the corr...