Timely Inhibition of Notch Signaling by DAPT Promotes Cardiac Differentiation of Murine Pluripotent Stem Cells

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成果类型：

期刊论文

作者：

Liu, Yinan;Li, Peng;Liu, Kaiyu;He, Qihua;Han, Shuo;...

通讯作者：

Li, Tao

作者机构：

[Liu, Yinan; Han, Shuo; Li, Peng; Shen, Li] Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Stem Cell Res Ctr, Beijing 100871, Peoples R China.

[Liu, Kaiyu] Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100871, Peoples R China.

[He, Qihua] Peking Univ, Sch Basic Med Sci, Ctr Med & Hlth Anal, Beijing 100871, Peoples R China.

[Sun, Xiaofeng] Hunan Univ Chinese Med, Inst Chinese Med, Dept Histol & Embryol, Changsha, Hunan, Peoples R China.

[Li, Tao] Zhejiang Normal Univ, Coll Chem & Life Sci, Dept Biol, Jinhua, Zhejiang, Peoples R China.

通讯机构：

[Li, Tao] Z

Zhejiang Normal Univ, Coll Chem & Life Sci, Dept Biol, Jinhua, Zhejiang, Peoples R China.

语种：

英文

关键词：

Notch signaling;Induced pluripotent stem cells;Cell differentiation;Stem cells;Mesoderm;Neuronal differentiation;Small interfering RNAs;Reverse transcriptase-polymerase chain reaction

期刊：

PLoS ONE

ISSN：

1932-6203

年：

2014

卷：

期：

页码：

e109588-

DOI：

10.1371/journal.pone.0109588

基金类别：

National Basic Research Program of China (973 program)National Basic Research Program of China [2011CB510200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31101057, 81303004]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [LY14C120001]

机构署名：

本校为其他机构

院系归属：

医学院

中医学院

摘要：

The Notch signaling pathway plays versatile roles during heart development. However, there is contradictory evidence that Notch pathway either facilitates or impairs cardiomyogenesis in vitro. In this study, we developed iPSCs by reprogramming of murine fibroblasts with GFP expression governed by Oct4 promoter, and identified an effective strategy to enhance cardiac differentiation through timely modulation of Notch signaling. The Notch inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester) alone drove the iPSCs to a neuronal fate. After mesoderm induction of em...

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Timely Inhibition of Notch Signaling by DAPT Promotes Cardiac Differentiation of Murine Pluripotent Stem Cells

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