期刊论文

He, Z.-Y.

中文

中国中药杂志

1001-5302

2004

29

12

1160-1165

10.3321/j.issn:1001-5302.2004.12.014

国家自然科学基金 （3 990 0 199）； 湖南省自然科学基金 （99JJY2 0 0 3 ）； 中国博士后基金 （2 0 0 3 0 3 45 2 1）；

本校为其他机构

目的:观察参麦注射液对大鼠脑出血后神经细胞凋亡相关基因的影响.方法:采用Rosenberg法复制大鼠脑出血模型,测定脑出血后大鼠海马CA1区神经细胞病理形态结构及其Bcl-2基因、Bax基因表达;结果:参麦注射液减少大鼠脑出血后海马CA1区锥体细胞凋亡数目,显著增加Bcl-2基因表达,降低Bax基因表达,使Bax mRNA/bcl-2 mRNA比率下降.结论:参麦注射液能调节凋亡基因,减少大鼠脑出血后神经细胞的凋亡.

Objective: To observe the effects of Shenmai(SM) injection on the neuronal apoptosis related gene expression in rat brain after intracerebral hemorrhage. Method: With Rosenberg models of rat intracerebral hemorrhage, we studied the pathologic changes of neuronal structure in hippocampal CA1 areas and gene expression of Bax and Bcl-2. Result: SM injection had effects on inhibiting the pyramidal cells apoptosis in the hippocampal CA1 areas, increasing the expression of Bcl-2 gene, and reducing the expression of Bax gene resulting deceased the ratio of Bax mRNA/Bcl-2 mRNA. Conclusion: SM injectio...