期刊论文

中文

江西中医药大学学报

2095-7785

2014

26

4

23-27

2012A060:江西省卫生计生委中医药科研项目 81273670:国家自然科学基金

本校为其他机构

目的：探讨动脉粥样硬化模型大鼠随着造模时间的推移“痰瘀”演变规律.方法：采用维生素D3复合高脂饲养复制大鼠模型,动态检测血脂、血液流变学、主动脉形态学、脂质代谢相关通路基因表达的变化.结果：随着动脉粥样硬化大鼠由痰到瘀的变化即血脂、血液流变学、主动脉形态学等指标均随病情加重而变化,脂质代谢相关通路基因表达也在逐渐改变.结论：脂质代谢相关通路基因的异常表达是动脉粥样硬化大鼠由痰到瘀的分子机制.

Objective：To explore the evolution law of phlegm and blood stasis of atherosclerosis rats with modeling time passed. Meth- ods ： The rat model was established using vitamin D3 combined with high - fat diet, and blood lipids, Hemorheology, Aortic Morphology and lipid metabolism related changes of pathway gene expression were dynamically detected. Results：Blood lipids, Hemorheology, Aortic Morphology and other index of atherosclerosis rats were changed as the disease got worse, meanwhile, Aortic Morphology and lipid metabolism related pathway ...