Resveratrol promotes skin wound healing by regulating the miR-212/CASP8 axis

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成果类型：

期刊论文

作者：

Liu, Yu;Xiong, Wu;Wang, Chu-Wang;Shi, Jian-Ping;Shi, Zhi-Qiang;...

通讯作者：

Zhou, Jian-Da

作者机构：

[Liu, Yu] Cent South Univ, Xiangya Hosp 3, Postdoctoral Res Stn Clin Med, Changsha 410000, Hunan, Peoples R China.

[Liu, Yu; Zhou, Jian-Da; Wang, Chu-Wang] Cent South Univ, Xiangya Hosp 3, Dept Plast Surg, Changsha 410000, Hunan, Peoples R China.

[Liu, Yu; Shi, Jian-Ping; Shi, Zhi-Qiang] Inner Mongolia Med Univ, Hohhot 010000, Inner Mongolia, Peoples R China.

[Xiong, Wu] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Burn & Plast Surg, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Zhou, Jian-Da] D

Department of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, P.R. China

语种：

英文

期刊：

Laboratory Investigation

ISSN：

0023-6837

年：

2021

卷：

101

期：

页码：

1363-1370

DOI：

10.1038/s41374-021-00621-6

基金类别：

Natural Science Fund Project of Inner Mongolia autonomous region [2018BS08009]; Inner Mongolia Medical University Science and Technology Million Project [YKD2017KJBW016]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2020JJ5861]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

The wound-healing process is a natural response to burn injury. Resveratrol (RES) may have potential as a therapy for wound healing, but how and whether RES regulates skin repair remains poorly understood. Human epidermal keratinocyte (HaCaT) cells were treated with lipopolysaccharide (LPS), and a mouse skin wound-healing model was established. Cell viability and apoptosis were analyzed by 3-(4,5-dimethyl-2-thiazolyl)−2,5-diphenyl-2-H-tetrazolium bromide or flow cytometry. Cell proliferation was assessed by cell viability and colony-formation ...

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Resveratrol promotes skin wound healing by regulating the miR-212/CASP8 axis

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