期刊论文

中文

合肥工业大学学报(自然科学版)

1003-5060

2016

39

4

566-569

10.3969/j.issn.1003-5060.2016.04.026

湖南省科技厅资助项目(2013FJ4054)； 湖南省教育厅科研资助项目(14C0850)； 湖南省药学重点学科资助项目； 湖南中医药大学“十二五”药物分析重点学科资助项目；

本校为第一机构

文章将阿魏酸经乙酰化后与SOCl_2反应制备酰氯,再以2.5%NaOH为催化剂,乙酰阿魏酰氯与丹皮酚拼接合成酯。对目标化合物进行了IR和~1H-NMR结构表征。由实验可得乙酰阿魏酸丹皮酚酯合成的最佳工艺如下:乙酰阿魏酰氯和丹皮酚的摩尔比为2∶1,反应时间为2 h,反应温度为15 ℃,2.5%NaOH的用量为6 mL。在该工艺条件下产物的收率可达到75.2%。因此以2.5%NaOH为催化剂合成乙酰阿魏酸丹皮酚酯,收率高,反应条件温和,操作简便。

The ferulic acid was first acetylated then halogenated with SOCl2 to prepare the acetylferuloyl chloride. By using NaOH with the concentration of 2. 5% as the catalyst, acetylferuloyl chloride and paeonol were esterificated into the acetylferulic paeonol ester. The structural characterization of target compound was identified by IR and 1 ^H-NMR. was 1 ： 2, the reaction time was 2 h, the reaction When the mole ratio of paeonol to acyl chloride temperature was 15 ℃ and the dosage of 2. 5% NaOH was 6 mL, a better yield of 75.2% could be gotten. ...