Objecfive:To observe the therapeutic effects of Toutongkang granules on migraine. Methods:90 cases of migraine were randomly divided into Toutongkang group (treatment group, 45 cases) and Xibiling (due to Ca 2+ antagonism) group (control group, 45,cases),and their therapeutic effects were compared. Results:Both groups can reduce the frequency, the continuous time, the intensity and the index of migraine, but the effect of treatment group was better than the control group (P