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Chaihu-Longgu-Muli decoction relieves epileptic symptoms by improving autophagy in hippocampal neurons

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成果类型:
期刊论文
作者:
Yang, Ping;Qin, You;Zhu, Yong;Li, Feng;Xia, Shuai-shuai;...
通讯作者:
Li, Liang;Huang, HY
作者机构:
[Yang, Ping; Zhou, Bin; Lu, Jun; Zhu, Yong; Wang, Qin] Hunan Univ Chinese Med, Hunan Brain Hosp, Dept Psychiat, Clin Med Sch, 427 Middle Furong Rd, Changsha 410007, Hunan, Peoples R China.
[Yang, Ping; Li, Liang; Xia, Shuai-shuai; Li, Feng; Huang, Hui-yong] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
[Qin, You] Hunan Acad Chinese Med, Inst Chinese Mat Med, 8 Yuehua Rd, Changsha 410013, Hunan, Peoples R China.
[Li, Feng] Univ Calif Los Angeles, Sch Dent, 405 Hilgard Ave, Los Angeles, CA 90095 USA.
[Huang, Hui-yong; Li, Liang] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Sci & Educ Pk, Changsha 410208, Yuelu District, Peoples R China.
通讯机构:
[Huang, HY ; Li, L] H
Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Sci & Educ Pk, Changsha 410208, Yuelu District, Peoples R China.
语种:
英文
关键词:
beclin 1;chaihu longgu muli decoction;Chinese drug;lithium chloride;mammalian target of rapamycin;microtubule associated protein;microtubule associated protein 5;microtubule associated proteins 1a 1b light chain 3;pilocarpine;unclassified drug;anticonvulsive agent;autophagy related protein;herbaceous agent;lithium chloride;pilocarpine;animal experiment;animal model;Article;autophagosome;autophagy (cellular);controlled study;dentate gyrus;drug mechanism;drug megadose;epilepsy;hippocampus;immunofluorescence test;loading drug dose;male;neuropharmacology;nonhuman;rat;real time reverse transcription polymerase chain reaction;transmission electron microscopy;Western blotting;animal;animal behavior;autophagy;disease model;drug effect;epilepsy;genetics;hippocampus;metabolism;nerve cell;pathology;pathophysiology;signal transduction;Sprague Dawley rat;ultrastructure;Animals;Anticonvulsants;Autophagosomes;Autophagy;Autophagy-Related Proteins;Behavior, Animal;Disease Models, Animal;Drugs, Chinese Herbal;Epilepsy;Hippocampus;Lithium Chloride;Male;Neurons;Pilocarpine;Rats, Sprague-Dawley;Signal Transduction
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2020
卷:
259
页码:
112990
基金类别:
This work was supported by grants from the National Natural Science Foundation of China (No.81603512 and 81874429), Major Science& Technology Projects of Hunan Province (2018SK1030), Natural Science Foundation of Hunan Province (No.2018JJ2289 and 2019JJ80027), Chinese Medicine Science&Research Project of Hunan Province (No. 201818), Foundation of Health Commission of Hunan Province (No. 20190058 and 20200009), and Foundation of Department of Education of Hunan Province (19B440). This work was supported by grants from the National Natural Science Foundation of China (No. 81603512 and 81874429 ), Major Science& Technology Projects of Hunan Province ( 2018SK1030 ), Natural Science Foundation of Hunan Province (No. 2018JJ2289 and 2019JJ80027 ), Chinese Medicine Science&Research Project of Hunan Province (No. 201818 ), Foundation of Health Commission of Hunan Province (No. 20190058 and 20200009 ), and Foundation of Department of Education of Hunan Province ( 19B440 ).
机构署名:
本校为第一且通讯机构
院系归属:
中医学院
中医诊断研究所
摘要:
Ethnopharmacological relevance: Chaihu-Longgu-Muli decoction (CLMD) is a well-known ancient formula in traditional Chinese medicine (TCM) to relieve disorder, clear away heat, tranquilize the mind and allay excitement. It has been used for the therapy of neuropsychiatric disorders such as epilepsy, dementia, insomnia, anxiety, and depression for several centuries in China. Aim of the study: This paper is based on the assumption that the mechanism by which CLMD relieves epileptic symptoms in rats is associated with improving autophagy. Several e...

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