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Chaihu-Longgu-Muli Decoction exerts an antiepileptic effect in rats by improving pyroptosis in hippocampal neurons

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成果类型:
期刊论文
作者:
Xia, Shuaishuai;Yang, Ping;Li, Feng;Yu, Qian;Kuang, Weiping;...
通讯作者:
Li, Liang;Huang, HY
作者机构:
[Wu, Huaying; Huang, Huiyong; Li, Liang; Yu, Qian; Xia, Shuaishuai] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.
[Wu, Huaying; Yu, Qian; Li, Liang; Li, Feng; Xia, Shuaishuai; Huang, Huiyong] Hunan Univ Chinese Med, Key Lab TCM Heart & Lung Syndrome Differentiat &, Changsha 410208, Hunan, Peoples R China.
[Yang, Ping; Kuang, Weiping; Lu, Jun; Zhu, Yong] Hunan Univ Chinese Med, Hunan Brain Hosp, Clin Med Sch, Dept Psychiat, Changsha 410007, Hunan, Peoples R China.
[Li, Feng] Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90095 USA.
通讯机构:
[Huang, HY ; Li, L] H
Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
carbamazepine;chaihu longgu muli decoction;Chinese drug;cryopyrin;interleukin 1beta;interleukin 1beta converting enzyme;lithium chloride;messenger RNA;pilocarpine;saikosaponin a;tumor necrosis factor;unclassified drug;anticonvulsive agent;Cap1 protein, rat;cryopyrin;cytoskeleton protein;herbaceous agent;IL1B protein, rat;interleukin 1beta;lithium chloride;Nlrp3 protein, rat;pilocarpine;tumor necrosis factor;animal cell;animal experiment;animal model;Article;controlled study;dentate gyrus;enzyme linked immunosorbent assay;epileptic state;hippocampus;immunofluorescence;immunofluorescence assay;male;nerve cell;nonhuman;pyroptosis;rat;real time polymerase chain reaction;seizure;temporal lobe epilepsy;animal;chemistry;disease model;drug effect;genetics;hippocampus;metabolism;nerve cell;pyroptosis;Sprague Dawley rat;temporal lobe epilepsy;Animals;Anticonvulsants;Cytoskeletal Proteins;Disease Models, Animal;Drugs, Chinese Herbal;Epilepsy, Temporal Lobe;Hippocampus;Interleukin-1beta;Lithium Chloride;Male;Neurons;NLR Family, Pyrin Domain-Containing 3 Protein;Pilocarpine;Pyroptosis;Rats, Sprague-Dawley;Tumor Necrosis Factor-alpha
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2021
卷:
270
页码:
113794
基金类别:
This work was supported by grants from the National Natural Science Foundation of China (No. 81874429 ), Key R&D program of Hunan Province (No. 2018SK1030 ), Natural Science Foundation of Hunan Province (No. 2020JJ5294 ), Traditional Chinese Medicine Science & Research Project of Hunan Province (No. 202145 ), Foundation of Department of Education of Hunan Province (No. 19B440 ). We are grateful for the support by the Institute of Diagnostics of TCM, Hunan University of Chinese Medicine, Changsha, China .
机构署名:
本校为第一且通讯机构
院系归属:
中医学院
临床医学院
中医诊断研究所
摘要:
Ethnopharmacological relevance: Chaihu-Longgu-Muli Decoction (CLMD) is a classic prescription created by Zhong-jing Zhang, a famous ancient Chinese medical scientist, to harmonize uncontrollable body activities and calm the minds. Now Traditional Chinese Medicine (TCM) physicians often apply it to treat psychiatric diseases such as epilepsy. Aim of the study: This study investigated the mechanism of the effect of Chaihu-Longgu-Muli Decoction (CLMD) on hippocampal neurons pyroptosis in rats with Temporal Lobe Epilepsy (TLE). Materials and method...

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