Chaihu-Longgu-Muli Decoction exerts an antiepileptic effect in rats by improving pyroptosis in hippocampal neurons

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成果类型：

期刊论文

作者：

Xia, Shuaishuai;Yang, Ping;Li, Feng;Yu, Qian;Kuang, Weiping;...

通讯作者：

Li, Liang;Huang, Huiyong

作者机构：

[Wu, Huaying; Li, Liang; Huang, Huiyong; Yu, Qian; Xia, Shuaishuai] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.

[Wu, Huaying; Yu, Qian; Li, Liang; Li, Feng; Xia, Shuaishuai; Huang, Huiyong] Hunan Univ Chinese Med, Key Lab TCM Heart & Lung Syndrome Differentiat &, Changsha 410208, Hunan, Peoples R China.

[Yang, Ping; Kuang, Weiping; Lu, Jun; Zhu, Yong] Hunan Univ Chinese Med, Hunan Brain Hosp, Clin Med Sch, Dept Psychiat, Changsha 410007, Hunan, Peoples R China.

[Li, Feng] Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90095 USA.

通讯机构：

[Li, L; Huang, HY] H

Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Chaihu-Longgu-Muli decoction;Hippocampal neurons;Pyroptosis;Temporal lobe epilepsy;Traditional Chinese medicine

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2021

卷：

270

页码：

113794-

DOI：

10.1016/j.jep.2021.113794

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81874429]; Key R&D program of Hunan Province [2018SK1030]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2020JJ5294]; Traditional Chinese Medicine Science & Research Project of Hunan Province [202145]; Foundation of Department of Education of Hunan Province [19B440]; Institute of Diagnostics of TCM, Hunan University of Chinese Medicine, Changsha, China

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

临床医学院

中医诊断研究所

摘要：

Ethnopharmacological relevance: Chaihu-Longgu-Muli Decoction (CLMD) is a classic prescription created by Zhong-jing Zhang, a famous ancient Chinese medical scientist, to harmonize uncontrollable body activities and calm the minds. Now Traditional Chinese Medicine (TCM) physicians often apply it to treat psychiatric diseases such as epilepsy. Aim of the study: This study investigated the mechanism of the effect of Chaihu-Longgu-Muli Decoction (CLMD) on hippocampal neurons pyroptosis in rats with Temporal Lobe Epilepsy (TLE). Materials and methods: The lithium chloride-pilocarpine-induced TLE ra...

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Chaihu-Longgu-Muli Decoction exerts an antiepileptic effect in rats by improving pyroptosis in hippocampal neurons

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