Downregulation of circAsxl2 Relieves Neuronal Injury Induced by oxygen-glucose deprivation/reperfusion

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Wen;Liu, Dan;Yi, Jian;Fan, Jianmin

通讯作者：

Fan, JM

作者机构：

[Zhang, Wen] Hunan Univ Chinese Med, Geriatr Dept, Hosp 1, Changsha 410007, Hunan, Peoples R China.

[Liu, Dan] Hunan Univ Chinese Med, Dept Rheumatol & Immunol, Hosp 1, Changsha 410007, Hunan, Peoples R China.

[Yi, Jian] Hunan Univ Chinese Med, Med innovat Ctr, Hosp 1, Changsha 410007, Hunan, Peoples R China.

[Fan, Jianmin] Hunan Univ Chinese Med, Dept Cardiovasc Dis, Hosp 1, 95 Shaoshan middle Rd, Changsha, Hunan, Peoples R China.

通讯机构：

[Fan, JM ] H

Hunan Univ Chinese Med, Dept Cardiovasc Dis, Hosp 1, 95 Shaoshan middle Rd, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Cerebral ischemia reperfusion injury;CircAsxl2;FOXO3;miR-130b-5p

期刊：

Molecular Neurobiology

ISSN：

0893-7648

年：

2023

DOI：

10.1007/s12035-023-03532-3

基金类别：

None.

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

BACKGROUND: Circular RNAs (circRNAs) have been shown to play an important role in cerebral ischemia-reperfusion (I/R) injury. However, the role of circAsxl2 (mmu_circ_0000346) in cerebral I/R injury remains unclear. METHODS: Mouse brain neuronal cell line (HT-22) was used to perform oxygen-glucose deprivation/reperfusion (OGD/R) treatment. The levels of circAsxl2, microRNA (miR)-130b-5p and forkhead box O3 (FOXO3) were determined using quantitative real-time PCR. Cell viability and apoptosis were measured using cell counting kit 8 assay and flow cytometry. Commercial kits were used to assess c...

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Downregulation of circAsxl2 Relieves Neuronal Injury Induced by oxygen-glucose deprivation/reperfusion

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