Metal-free direct cyanoisopropylation/arylation of N-arylacrylamides or N-alkyl-N-(arylsulfonyl) acrylamides with AIBN: a simple and mild approach to cyano-containing oxindoles
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21372068]
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摘要：
A simple and metal-free direct cyanoisopropylation/arylation of N-arylacrylamides or N-alkyl-N-(arylsulfonyl)acrylamides with AIBN has been developed with cheap and readily available CH3NO2as both the solvent and the oxidant. This reaction provides an efficient approach to cyano-containing oxindoles, which are highly valued synthetic intermediates of biologically active molecules. A series of N-alkyl-N-(arylsulfonyl)acrylamide substrates could be converted into the corresponding oxindoles in good yields and with excellent chemoselectivity via one-pot cyanoisopropylation/aryl migration/desulfon...
