N6-methyladenosine profiling reveals that Xuefu Zhuyu decoction upregulates METTL14 and BDNF in a rat model of traumatic brain injury

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成果类型：

期刊论文

作者：

Feng, Dandan;Li, Pengfei;Xiao, Wei;Pei, Zhuan;Chen, Peishun;...

通讯作者：

Wang, Y

作者机构：

[Xia, Zian; Hu, Mingrui; Wang, Yang; Xiao, Wei; Pei, Zhuan; Chen, Peishun; Yang, Zhaoyu; Feng, Dandan; Cui, Hanjin; Tang, Tao; Li, Teng] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Tradit Chinese & Western Med, Changsha 410008, Peoples R China.

[Xia, Zian; Huang, Qing; Hu, Mingrui; Xiao, Wei; Pei, Zhuan; Wang, Yang; Chen, Peishun; Yang, Zhaoyu; Feng, Dandan; Cui, Hanjin; Tang, Tao; Li, Teng] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China.

[Li, Pengfei] Zhengzhou Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Zhengzhou 450052, Peoples R China.

[Li, Haigang] Changsha Med Univ, Hunan Key Lab Res & Dev Novel Pharmaceut Preparat, Changsha 410219, Peoples R China.

[Huang, Qing] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Peoples R China.

通讯机构：

[Wang, Y ] C

Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Tradit Chinese & Western Med, Changsha 410008, Peoples R China.

语种：

英文

关键词：

Brain-derived neurotrophic factor;Epitranscriptional regulation;METTL14;N(6)-methyladenosine;Traumatic brain injury;Xuefu Zhuyu decoction

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2023

卷：

317

页码：

116823

DOI：

10.1016/j.jep.2023.116823

基金类别：

National Natural Science Foundation of China [81973665, 82204892]; Hunan Provincial Natural Science Foundation of China [2023JJ40938, 2023JJ30944]; Science and Technology Innovation Program of Hunan Province [2021RC3030]; Shennong Youth Scholar Project of Hunan [2022]

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: The traditional Chinese herbal formula Xuefu Zhuyu decoction (XFZYD) is a classic formula in the category of invigorating blood circulation and resolving blood stasis. It has been proven to improve the neurological and ethological prognosis of traumatic brain injury. XFZYD promotes synaptic and axonal regeneration after traumatic brain injury, which is functionally modulated by the N(6)-methyladenosine (m(6)A) modification of RNA. However, the epigenetic effects of XFZYD on m(6)A modification remain unknown. AIM OF THE STUDY: To explore how XFZYD protects agains...

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N6-methyladenosine profiling reveals that Xuefu Zhuyu decoction upregulates METTL14 and BDNF in a rat model of traumatic brain injury

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