Oleanolic acid inhibits RANKL-induced osteoclastogenesis via ER alpha/miR-503/RANK signaling pathway in RAW264.7 cells

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成果类型：

期刊论文

作者：

Xie, Bao-ping;Shi, Li-ying;Li, Jin-ping*;Zeng, Ying*;Liu, Wei;...

通讯作者：

Li, Jin-ping;Zeng, Ying

作者机构：

[Li, Jin-ping; Shi, Li-ying; Xie, Bao-ping; Jia, Lu-juan] Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmachem, 172 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.

[Zeng, Ying] Hunan Univ Tradit Chinese Med, Hosp 1, 105 Shao Shan Rd, Changsha 410007, Hunan, Peoples R China.

[Liu, Wei; Tang, Si-yuan] Cent South Univ, Sch Nursing, 172 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.

[Zhang, Jie] Cent South Univ, Xiangya Hosp 3, 172 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.

[Gan, Guo-xing] Qing Yuan Hosp Tradit Chinese Med, 10 Qiao Bei Rd, Qing Yuan 511500, Guangdong, Peoples R China.

通讯机构：

[Li, Jin-ping] C

[Zeng, Ying] H

Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmachem, 172 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.

Hunan Univ Tradit Chinese Med, Hosp 1, 105 Shao Shan Rd, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

Estrogen receptor alpha (ERalpha);Methylpiperidino pyrazole;MicroRNA-503;Oleanolic acid;Osteoclasts;Osteoporosis

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2019

卷：

117

期：

117

页码：

109045

DOI：

10.1016/j.biopha.2019.109045

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81273816, 81774379]; Natural Science Foundation of Hunan Province in ChinaNatural Science Foundation of Hunan Province [2017JJ2338]; Qingyuan Industrial Technology and Research Development Fund of Guangdong Province in China [2016A020]

机构署名：

本校为通讯机构

院系归属：

第一中医临床学院

摘要：

Oleanolic acid (OA) has recently become a research hotspot in the treatment of many human diseases, especially osteoporosis and arthritis. However, the mechanisms are not elucidated completely. We aimed to elucidate the target and the mechanism via which OA inhibited osteoclast differentiation. We used TRAP staining and toluidine blue dye to test OA effect on osteoclastogenesis and bone resorption respectively. We detected the expression level of osteoclast differentiation related genes, estrogen receptor alpha (ER alpha) and miR-503. We blocked ER alpha with its specific blocker, methylpiperi...

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Oleanolic acid inhibits RANKL-induced osteoclastogenesis via ER alpha/miR-503/RANK signaling pathway in RAW264.7 cells

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