Wnt5a and its signaling pathway in angiogenesis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shi, Ya-Ning;Zhu, Neng;Liu, Chan;Wu, Hong-Tao;Gui, Yu;...

通讯作者：

Qin, Li

作者机构：

[Liu, Chan; Shi, Ya-Ning; Liao, Duan-Fang; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Changsha, Hunan, Peoples R China.

[Shi, Ya-Ning; Qin, Li] Hunan Univ Chinese Med, Hunan Prov Engn Res Ctr, Bioact Subst Discovery Chinese Med, Changsha, Hunan, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Dept Urol, Hosp 1, Changsha, Hunan, Peoples R China.

[Wu, Hong-Tao] Cent S Univ, Xiangya Hosp 2, Dept Urol, Changsha, Hunan, Peoples R China.

[Gui, Yu] Univ Calgary, Cumming Sch Med, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Qin, Li] H

Hunan Univ Chinese Med, Sch Pharm, Hanpu Sci & Educ Dist, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Angiogenesis;Signaling pathway;Wnt5a

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2017

卷：

471

页码：

263-269

DOI：

10.1016/j.cca.2017.06.017

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270359, 81670268]; projects of Hunan Provincial Education Department [15A138, 16C1210]; Key projects of Hunan traditional Chinese Medicine Administration [201614]; Key project of National Bureau of Foreign Experts [20164300059]; Natural Science Foundation of Guangxi ProvinceNational Natural Science Foundation of Guangxi Province [2015GXNSFEA139003]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

Wnt5a, a secreted glycoprotein, belongs to the noncanonical Wnt family involved in a wide range of organism development and tissue homeostasis. Wnt5a and its signaling pathway can regulate fundamental cellular processes, including specification of cell fate, proliferation, and survival. Accumulating evidence indicates that Wnt5a exhibits dual effects on angiogenesis. The formation of new blood vessels derives from pre-existing vessels via canonical and non-canonical Wnt pathways, depending on cell types, receptors, downstream effectors, and microenvironment. Given that the regulation of angiog...

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Wnt5a and its signaling pathway in angiogenesis

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