Exploration of the Potential Mechanism of Calculus Bovis in Treatment of Primary Liver Cancer by Network Pharmacology

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成果类型：

期刊论文

作者：

Zhang, Zhen;Zeng, Puhua;Gao, Wenhui;Wu, Ruoxia;Deng, Tianhao;...

通讯作者：

Tian, XF

作者机构：

[Tian, Xuefei; Tian, XF; Zhang, Zhen] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med, Changsha 410208, Hunan, Peoples R China.

[Tian, Xuefei; Tian, XF; Zhang, Zhen; Wu, Ruoxia] Hunan Univ Chinese Med, Hunan Key Lab TCM Prescript & Syndromes Translat, Changsha 410208, Peoples R China.

[Deng, Tianhao; Zeng, Puhua; Chen, Siqin] Hunan Acad Tradit Chinese Med, Afilliated Hosp, Changsha 410006, Peoples R China.

[Gao, Wenhui; Wu, Ruoxia] Hunan Univ Chinese Med, Sch Chinese Med, Changsha 410208, Peoples R China.

通讯机构：

[Tian, XF ] H

Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Hunan Key Lab TCM Prescript & Syndromes Translat, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Antitumor activity;Calculus bovis;Chemotherapy;Chinese medicine;Network pharmacology;Primary liver cancer

期刊：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

ISSN：

1386-2073

年：

2021

卷：

期：

页码：

129-138

DOI：

10.2174/1386207323666200808172051

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant no. 8160360,81473617); Hunan Science and Technology Department of China (Grant no. 2015JC3075).

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

摘要：

Aim and Objective:Calculus Bovis (CB) has been employed to treat diseases for a long time. It has been identified to play significant anti-inflammatory and anti-tumor roles. However, the mechanism of treating primary liver cancer (PLC) remains to be revealed. This study aims to clarify the molecules and mechanisms of CB in treating PLC.Materials and Methods:After oral bioavailability (OB) and drug-likeness (DL) screening, 15 small molecules were identified as the potential ingredients against PLC. Following this, related targets network constructions and pathways were applied to clarify the me...

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Exploration of the Potential Mechanism of Calculus Bovis in Treatment of Primary Liver Cancer by Network Pharmacology

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