Antimicrobial activity-guided identification of compounds from the deciduous leaves of Malus doumeri by HPLC-ESI-QTOF-MS/MS

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成果类型：

期刊论文

作者：

Shen, Bingbing;Zhou, Rongrong;Yang, Yupei;Li, Jiayu;Liang, Xuejuan;...

通讯作者：

Zhang, Shuihan

作者机构：

[Li, Jiayu; Zhang, Shuihan; Liang, Xuejuan; Chen, Lin; Shen, Bingbing] Hunan Acad Chinese Med, Res Inst Chinese Med, Changsha, Hunan, Peoples R China.

[Zhou, Rongrong] Changchun Univ Chinese Med, Sch Pharm, Changchun, Jilin, Peoples R China.

[Li, Jiayu; Yang, Yupei] Hunan Univ Chinese Med, Sch Pharm, Changsha, Hunan, Peoples R China.

[Huang, Luqi] China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, Beijing, Peoples R China.

通讯机构：

[Zhang, Shuihan] H

Hunan Acad Chinese Med, Res Inst Chinese Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Antimicrobial activity;the deciduous leaves;Malus doumeri;HPLC-ESI-QTOF-MS/MS

期刊：

Natural Product Research

ISSN：

1478-6419

年：

2019

卷：

期：

页码：

2515-2520

DOI：

10.1080/14786419.2018.1457666

基金类别：

Hunan Science and Technology Key Project [2012SK2008]; Hunan Natural Science Foundation Project [2016JJ4056]

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

This paper intends to identify the antimicrobial activity compounds from the deciduous leaves of Malus doumeri (Dong Li Tea) by HPLC-ESI-QTOF-MS/MS. The ethanol extracts of Malus doumeri were partitioned into petroleum ether, dichloromethane, ethyl acetate, n-butanol and water fraction, respectively. The antimicrobial screening experiments showed that ethyl acetate fraction has a certain antibacterial activity by inhibition zone method in vitro. And then we used the HPLC-ESI-QTOF-MS/MS method to verify the identities of bioactive compounds. Finally, 41 compounds were determined and 11 of which...

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Antimicrobial activity-guided identification of compounds from the deciduous leaves of Malus doumeri by HPLC-ESI-QTOF-MS/MS

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