【Abstract】 Acne is a chronic inflammatory dermatosis of pilosebaceous units. Increased sebum content is the precondition of acne occurrence, and changes of sebum components promote inflammatory reactions in acne. Imbalance of sebum homeostasis is one of the key factors for acne occurrence. Due to the complex composition and diverse structure of sebum, it is difficult to analyze all lipid compounds in sebum by using a single experimental method. Lipidomics can be used to qualitatively and quantitatively analyze hundreds of lipids with different properties and biological activities, which provides a potential insight into the role of sebum in the pathogenesis of acne. This review summarizes application of lipidomics in the analysis of sebum in acne patients. 【Key words】 Acne vulgaris; Fatty acids, nonesterified; Squalene; Ceramides; Peroxisome proliferator⁃ activated receptors; Lipidomics; Sebum homeostasis imbalance Fund programs: Scientific Research Project of Hunan Education Department （18A212）; Clinical Medical Technology Innovation Guidance Project of Hunan Province（2018SK51102）; Hunan Postgraduate Research and Innovation Project（CX2018B501）;“225”Project to Train High⁃level Health Personnel in Hunan Province DOI: 10.35541/cjd.20190535
