期刊论文

Effect of pomegranate peel polyphenols on sebaceous gland spots and AKT/Sox9 signaling pathway in golden hamsters

Zhu, M.

中文

中华皮肤科杂志

0412-4030

2021

54

8

705-708

10.35541/cjd.20200569

【 Key words 】 Acnevulgaris;Pericarpiumgranati;Sebaceousglands;Sebum;SOX9transcription factor;Mesocricetus Fund programs: Scientific Research Project of Hunan Education Department （ 18 A212 ） ; Scientific Research Project of Hunan Health Commission（ 20201862 ） ;“225” Project to Train High⁃level Health PersonnelinHunanProvince;QualityEngineeringforGraduateStudentsofHunanUniversityofChinese Medicine （ 2018 CX50 ） DOI: 10.35541/cjd.20200569

本校为第一机构

目的:探讨石榴皮多酚对金黄地鼠皮脂分泌的影响及作用机制。方法:将30只金黄地鼠随机分为基质组和0.48%、0.96%、1.92%石榴皮多酚软膏组及维A酸乳膏组，每组6只，分别于双侧皮脂腺斑处涂抹1 g相应的软膏或乳膏连续4周，每日2次，于干预后第0、7、14、21、28天测量双侧皮脂腺斑，以最大纵径×最大横径来计算皮脂腺斑面积，并采用免疫组化法检测皮脂腺斑AKT/sox9信号通路表达水平。各组间不同时间点皮脂腺斑面积大小采用重复测量方差分析，其他数据采用单因素方差分析或Kruskal-Wallis H检验。 结果:0.96%石榴皮多酚组金黄地鼠皮脂腺斑面积为（50.48±2.41）mm 2，1.92%石榴皮多酚组为（48.24...

Objective:To evaluate the effect of pomegranate peel polyphenols on sebum secretion in golden hamsters, and to explore its possible mechanisms.Methods:Thirty golden hamsters were randomly and equally divided into 5 groups: (ointment) vehicle group, 0.48%-, 0.96%-, 1.92%-pomegranate peel polyphenol ointment groups, and retinoic acid cream group. Corresponding cream or ointments were applied to bilateral sebaceous gland spots of the golden hamsters at a dose of 1 gram twice a day for 4 consecutive weeks. The area of bilateral sebaceous gland spot...