期刊论文

The Vascular Smooth Muscle Cells Proliferation Induced by Thermal Injury in the Rabbit Central Ear Artery

中文

实用预防医学

1006-3110

2005

12

2

270-272

10.3969/j.issn.1006-3110.2005.02.021

本校为第一机构

目的探索建立热刺激动脉诱发血管平滑肌细胞增生的动物模型.方法兔耳中央动脉中间2 cm处被热水(43±0.5)℃刺激,每天一次,每次3 h,共做3次.分别于造模后3 d、1周、2周、4周时取材,石蜡切片.光学显微镜及图象分析仪进行形态学观察.结果中膜成分增生并突入血管腔内,造成管腔变狭.造模4周时管腔面积与造模3 d时、造模7 d时相比明显缩小(2.58±0.35)mm2/100比(3.25±0.59)mm2/100、(3.14±0.24)mm2/100,P＜0.05.造模4周时中膜厚度及平滑肌细胞层数与造模3 d时、造模7 d时相比明显增加(100.5±15.5)tm比(69.2±16.1)μm、(71.4±16.3)μm,P＜0.05;(11.6±0.8)层比(7.2±1.1)层、(6.5±1.7)层,P＜0.05...

Objective To build a new animal model of the vascular smooth muscle cells proliferation induced by thermal injury in the rabbit central ear artery. Methods The central artery of the rabbit ear was stimulated by warm water ( 43 ± 0.5 ℃ ) at the middle 2 cm for 3 hours daily for 3 days. Animals were killed at different time points, and tissue sections were examined under light microscope and digital image analysis system. Results The central artery of the rabbit ear responded to warm water, including the vascular smooth muscle cells proliferati...