期刊论文

EFFECT OF PHENCYCLIDINE ON CORONARY ARTERY FLOW IN THE ISOLATED HEART OF THE QUINEA-PIG

中文

复旦学报. 医学版

Journal of Fudan University(Medical Science)

1005-202X

1994

21

2

342-347

本校为其他机构

应用离体豚鼠心脏灌流法观察苯环利定对豚鼠冠脉流量的影响。结果：１０μｌ ＰＣＰ（０．１～１００μｍｏｌ／Ｌ）由动脉套管侧支于３０ｓ内恒速注入冠脉内，剂量依赖性地使冠脉流量减少，由给药前的１０．５ｍｌ／ｍｉｎ分别减少了１．４ｍｌ／ｍｉｎ ２．６ｍｌ／ｍｉｎ、３．５ｍｌ／ｍｉｎ和５．４ｍｌ／ｍｉｎ；ＰＣＰ受体特异性拮抗剂右吗喃和Ｓｉｇｍａ受体拮抗剂氟哌啶醇均可以拮抗ＰＣＰ收缩冠脉的作用，使冠脉流量分别

The effect of phencyclidine(PCP) was studied by its perfusion through the isolated heart and coronaries.The coronary arterial flow decreased 1.4ml/min,2.6 ml/min,3.5ml/min and 5.4 ml/min from 10.5 ml/min,respectively,in a concentration-dependent manner after 100μl PCP(0.1,1,10,100μmol/L)was injected in to the lateral branch of the artery eannula at a constant rate within 30s(compared with the control,P