期刊论文

Cai, G.-X.

英文

中国组织工程研究

2095-4344

2004

8

22

4532-4533

10.3321/j.issn:1673-8225.2004.22.081

国家自然科学基金资助(30300470)； 中国博士后科学基金(2003033478)； 湖南省自然科学基金资助(02JJY2054)~~；

本校为第一机构

Aim: To observe the effect of buyang huanwu tang on the reaction of endogenous neural stem cells(NSCs) after focal cerebral ischemia in rats, so as to explore its possible mechanism. Methods: Totally 84 male SD rats were randomly divided into 3 groups: sham operation group, model group and buyang huanwu tang group, focal cerebral ischemic models were induced by the thread occlusion method, which received different treatments, and then the rats were killed at 12 hours, 1, 3, 5 and 7 days after operation. The activation of NSC was determined in a...

目的:观察中药补阳还五汤对大鼠局灶性脑缺血后内源性神经干细胞(neural stem cells,NSC)反应的影响探讨其可能机制.方法:84只雄性SD大鼠随机分为假手术组、模型组、补阳还五汤组,采用线栓法复制大鼠脑缺血模型,分别给予不同处理,于术后12 h,1,3,5,7 d处死动物,运用免疫组织化学方法检测脑缺血后各组NSC的激活.另取5只大鼠为正常对照组.结果:正常大鼠脑组织中存在少量NSC,主要分布在皮质区;脑缺血后,NSC增殖,以皮质、缺血周围区增加明显,健侧海马区可见NSC激活;1 d开始增多,5 d达高峰,模型组1,3,5,7 d NSC数分别为(10.3±1.3),(14.2±1.7),(18.3±1.2),(16.4±1.6)个,补阳还五汤则分别为(10.8±...