Inhibitory effects of 3α-hydroxy-lup-20(29)-en-23, 28-dioic acid on lipopolysaccharide-induced TNF-α, IL-1β, and the high mobility group box 1 release in macrophages

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Xiang-Qian*;Zou, Qin-Peng;Huang, Jian-Jun;Yook, Chang-Soo;Whang, Wan-Kyunn;...

通讯作者：

Liu, Xiang-Qian

作者机构：

[Liu, Xiang-Qian] Hunan Univ Chinese Med, Sch Pharm, Changsha, Hunan, Peoples R China.

[Zou, Qin-Peng; Liu, Xiang-Qian] Cent S Univ, Sch Chem & Chem Engn, Changsha, Hunan, Peoples R China.

[Zou, Qin-Peng] Changsha Broad Ocean Biosci & Tech Co Ltd, Changsha, Hunan, Peoples R China.

[Huang, Jian-Jun] Cent S Univ, Dept Clin Biochem, Xiangya Med Coll, Changsha, Hunan, Peoples R China.

[Yook, Chang-Soo] Kyung Hee Univ, Coll Pharm, Seoul, South Korea.

通讯机构：

[Liu, Xiang-Qian] H

[Liu, Xiang-Qian] C

Hunan Univ Chinese Med, Sch Pharm, Changsha, Hunan, Peoples R China.

Cent S Univ, Sch Chem & Chem Engn, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

3alpha-hydroxy-lup-20(29)-en-23,28-dioic acid;HMGB1;IL-1beta;TNF-alpha;anti-inflammatory

期刊：

Bioscience, Biotechnology, and Biochemistry

ISSN：

0916-8451

年：

2017

卷：

期：

页码：

1305-1313

DOI：

10.1080/09168451.2017.1301803

基金类别：

This work was supported by Natural Science Foundation of Hunan Province, China [grant number 11JJ2042]; Key Projects of Changsha City Science and Technology Bureau [grant number k1403122-31].

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

We investigated the anti-inflammatory effects of 3α-hydroxy-lup-20(29)-en-23, 28-dioic acid (HLEDA) - a lupane-type triterpene isolated from leaves of Acanthopanax gracilistylus W. W. Smith (AGS), as well as the underlying molecular mechanisms in lipopolysaccharide (LPS)-induced RAW264.7 cells. Our results demonstrated that HLEDA concentration-dependently reduced the production of nitric oxide (NO), significantly suppressed LPS-induced expression of TNF-α and IL-1β at the mRNA and protein levels in RAW264.7 cells. Further analysis revealed t...

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Inhibitory effects of 3α-hydroxy-lup-20(29)-en-23, 28-dioic acid on lipopolysaccharide-induced TNF-α, IL-1β, and the high mobility group box 1 release in macrophages

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